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As people age, the incidence of prostate hyperplasia increases. So patients under Transurethral Resection of Prostate(TURP) or Holmium Laser Ennucleation of Prostate(HoLEP) are mostly ole age people. Most old age patient has several underlying disease. So patients can develop high mortality and morbidity. Most surgeries for Prostate Resection are taken under Spinal anesthesia. Adequate block level for Prostate Resection is T10. But sometimes, old age patients can develop severe complication after spinal anesthesia. So we started this study to know the adequate drug concentration for Spinal anesthesia taken for Prostate Resection surgery.
As people age, the incidence of prostate hyperplasia increases. So patients under Transurethral Resection of Prostate(TURP) or Holmium Laser Ennucleation of Prostate(HoLEP) are mostly ole age people. Most old age patient has several underlying disease. So patients can develop high mortality and morbidity. Most surgeries for Prostate Resection are taken under Spinal anesthesia. Adequate block level for Prostate Resection is T10. But sometimes, old age patients can develop severe hypotension and vital unstability due to unintentional high sensory and motor blocks. These complications are due to the decreased cerebrospinal fluid volume with increase of age. So we started this study to know the adequate drug concentration for Spinal anesthesia taken for Prostate Resection surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| bupivacaine 6mg | Other | bupivacaine 6mg |
|
| bupivacaine 7mg | Other | bupivacaine 7mg |
|
| bupivacaine 8mg | Other | bupivacaine 8mg |
|
| bupivacaine 9mg | Other | bupivacaine 9mg |
|
| bupivacaine 10mg | Other | bupivacaine 10mg |
|
| bupivacaine 11mg | Other | bupivacaine 11mg |
|
| bupivacaine 12mg | Other |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bupivacaine | Drug | bupivacaine dose |
|
| Measure | Description | Time Frame |
|---|---|---|
| ED50 and ED95 of intrathecal hyperbaric bupivacaine with fentanyl for transurethral prostatectomy in elderly patients | ED50(50% Effective dose) and ED95(95% Effective dose) of intrathecal hyperbaric bupivacaine with fentanyl for transurethral prostatectomy in elderly patients | 2years |
| Measure | Description | Time Frame |
|---|---|---|
| comparison of incidence of complications(hypotension, nausea/vomiting and shivering) during perioperative period | comparison of incidence of complications(hypotension, nausea/vomiting and shivering) during perioperative period | 2years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eun Mi Choi, MD | Hallym University Kangnam Sacred Heart Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kangnam sacred heart hospital | Seoul | Yeongdeungpo-gu | KS013 | South Korea |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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bupivacaine 12mg |
|
| D000588 |
| Amines |