Clinical Comparison of Femoral Nerve Versus Adductor Cana... | NCT03704376

Status Module

Name	Class
Memorial Hermann Hospital	OTHER

Description Module

Detailed Description

Adequate pain control following anterior cruciate ligament reconstruction (ACL) often requires a regional nerve block. The femoral nerve block (FNB) has been traditionally employed. More recently, ultrasound application to regional nerve blocks allows for the use of alternatives such as the adductor canal block following ACL reconstruction. In 2009, Manickam et al. were the first to describe the ultrasound guided adductor canal technique for the purposes of knee joint analgesia. Unlike other traditional techniques that seek to cause a sensory as well as a motor blockade, the adductor canal block attempts to spare the motor block of the neighboring distributions in an attempt to offer selective analgesia and strength preservation. Chisholm et al demonstrated the adductor canal block provides similar and adequate postoperative analgesia when compared to the FNB, following arthroscopic ACL reconstruction with patellar tendon autograft. Their study focused on analgesia and did not evaluate quadriceps function or impact on rehabilitation. Sharma et al drew the first association between femoral nerve blocks and increased fall risk due to muscle weakness in total knee arthroplasty population. A randomized, blinded study to compare quadriceps strength following adductor canal versus FNB was performed by Kwofie et al. They showed that compared with FNB, adductor canal block results in significant quadriceps motor sparing and significantly preserved balance. These studies focused on acute muscle weakness after regional anesthesia and its relation to safety. Quadriceps function is very important in rehabilitation of ACL reconstruction. Luo et al demonstrated long term deficits related to FNB. They demonstrated that patients treated with FNB after ACL reconstruction had significant isokinetic deficits in knee extension and flexion strength at 6 months when compared with patients who did not receive a nerve block. Patients without a block were 4 times more likely to meet criteria for clearance to return to sports at 6 months. In addition, Krych et al found significantly inferior quadriceps strength and function at 6 months in FNB group. Based on the available literature, we aim to compare femoral nerve versus adductor canal block in regards to pain control and muscle strength in ACL reconstruction patients until return to sport.

Design Module

Interventional Study Design

Biospecimen

No data available

No data is available for this block.

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Femoral Nerve Blockade	Active Comparator	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation.	Drug: 30 ml of 0.2% ropivacaine Drug: 100 mcg clonidine Device: High-frequency linear ultrasound transducer
Adductor Canal Blockade	Active Comparator	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ).	Drug: 15 ml of 0.2% ropivacaine Drug: 100 mcg clonidine Device: High-frequency linear ultrasound transducer

Name	Type	Description	Arm Group Labels	Other Names
30 ml of 0.2% ropivacaine	Drug		Femoral Nerve Blockade
15 ml of 0.2% ropivacaine

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Quadriceps Muscle Activation as Assessed by Surface Electromyography (sEMG)	Quadriceps muscle activation was examined using surface electromyography (sEMG) of the vastus medialis oblique muscle. Peak sEMG activity was recorded in microvolts (uV) on the surgical and contralateral limbs while performing five maximal effort isometric contractions in full knee extension--the reported values are equal to the quadriceps sEMG in uV of the contralateral limb minus the quadriceps sEMG in uV of the surgical limb.	Post-operative day 1
Quadriceps Muscle Activation as Assessed by Surface Electromyography (EMG)	Quadriceps muscle activation was examined using surface electromyography (sEMG) of the vastus medialis oblique muscle. Peak sEMG activity was recorded in microvolts (uV) on the surgical and contralateral limbs while performing five maximal effort isometric contractions in full knee extension--the reported values are equal to the quadriceps sEMG in uV of the contralateral limb minus the quadriceps sEMG in uV of the surgical limb.	Post-operative day 14
Quadriceps Muscle Activation as Assessed by Surface Electromyography (EMG)	Quadriceps muscle activation was examined using surface electromyography (sEMG) of the vastus medialis oblique muscle. Peak sEMG activity was recorded in microvolts (uV) on the surgical and contralateral limbs while performing five maximal effort isometric contractions in full knee extension--the reported values are equal to the quadriceps sEMG in uV of the contralateral limb minus the quadriceps sEMG in uV of the surgical limb.	4 weeks post operative

Secondary Outcomes

Measure	Description	Time Frame
Number of Successful Repetitions With Straight Leg Raise Test	The straight leg raise assessment was performed in a standardized long-sitting position with well-knee flexed to 90 degrees. Patients were asked to complete 30 repetitions of straight leg raises with a small bolster supporting the heel using the following criteria; (1) perform with no visible quad lag (2) reach the height of the opposite tibial tubercle and (3) maintain a controlled rate of 30 hertz for the ascending and descending phases. The examination was only performed on the surgical limb and the absolute number of successful repetitions is reported.

Eligibility Module

Name	Affiliation	Role
Lane Bailey, PhD, PT	The University of Texas Health Science Center, Houston	Principal Investigator

Facility	Status	City	State	ZIP	Country	Contacts
The University of Texas Health Science Center-Houston		Houston	Texas	77030	United States

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
37152546	Derived	Duncan BR, Reid M, Kleihege J, Higbie S, Gardner EP, Lowe W, Bailey L. Comparison of Psychological Readiness to Return to Sport After Primary Versus Revision Anterior Cruciate Ligament Reconstruction. Orthop J Sports Med. 2023 May 2;11(5):23259671231159408. doi: 10.1177/23259671231159408. eCollection 2023 May.
36860772	Derived

Results Section

Participant Flow Module

Arm/Group Information

ID	Title	Description
FG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Baseline Characteristics Module

Outcome Measures Module

Adverse Events Module

More Info Module

Type	Includes Protocol	Includes SAP	Includes ICF	Document Label	Document Date	Document Uploaded Date	Document File Name
Prot_SAP	Yes	Yes	No	Study Protocol and Statistical Analysis Plan	Feb 2, 2016

Arm/Group Information

ID	Title	Description
BG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
BG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
BG002	Total	Total of all reporting groups

Units	Counts
Participants	BG00038 BG00140 BG00278

Baseline Measures

Title

Description

Population Description

Parameter Type

Dispersion Type

Unit of Measure

Calculate Percentage

Denominator Units Selected

Denominators

Classes

Age, Continuous

Mean

Standard Deviation

years

Title

Denominators

Categories

Title	Measurements
	OG000266.5± 52.4 OG001212.5± 65.1

Primary

Quadriceps Muscle Activation as Assessed by Surface Electromyography (EMG)

Posted

Mean

Standard Deviation

microvolts (uV)

Post-operative day 14

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Primary

Quadriceps Muscle Activation as Assessed by Surface Electromyography (EMG)

Posted

Mean

Standard Deviation

microvolts (uV)

4 weeks post operative

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Secondary

Number of Successful Repetitions With Straight Leg Raise Test

The straight leg raise assessment was performed in a standardized long-sitting position with well-knee flexed to 90 degrees. Patients were asked to complete 30 repetitions of straight leg raises with a small bolster supporting the heel using the following criteria; (1) perform with no visible quad lag (2) reach the height of the opposite tibial tubercle and (3) maintain a controlled rate of 30 hertz for the ascending and descending phases. The examination was only performed on the surgical limb and the absolute number of successful repetitions is reported.

Posted

Mean

Standard Deviation

number of repetitions

Post-operative day 1

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Secondary

Number of Successful Repetitions With Straight Leg Raise Test

Posted

Mean

Standard Deviation

number of repetitions

Post-operative day 14

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Secondary

Number of Successful Repetitions With Straight Leg Raise Test

Posted

Mean

Standard Deviation

number of repetitions

4 weeks post operative

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Secondary

Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale

The items are scored on a visual analogical scale from 0-10, 0 being the better outcome.

Posted

Mean

Standard Deviation

units on a scale

1 hr post surgery

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Units	Counts
Participants

Secondary

Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale

The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome.

Posted

Mean

Standard Deviation

units on a scale

2 hr post surgery

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Units	Counts
Participants

Secondary

Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale

The items are scored on a visual analogical scale from 0-10, with 0 being the better

Posted

Mean

Standard Deviation

units on a scale

3 hr post surgery

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Units	Counts
Participants

Secondary

Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale

The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome.

Posted

Mean

Standard Deviation

units on a scale

4 hr post surgery

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Units	Counts
Participants

Secondary

Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale

The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome.

Posted

Mean

Standard Deviation

units on a scale

5 hr post surgery

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Units	Counts
Participants

Secondary

Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale

The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome.

Posted

Mean

Standard Deviation

units on a scale

6 hr post surgery

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Units	Counts
Participants

Secondary

Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale

The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome.

Posted

Mean

Standard Deviation

units on a scale

7 hr post surgery

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Units	Counts
Participants

Secondary

Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale

The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome.

Posted

Mean

Standard Deviation

units on a scale

8 hr post surgery

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Units	Counts
Participants

Secondary

Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale

The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome.

Posted

Mean

Standard Deviation

units on a scale

9 hr post surgery

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Units	Counts
Participants

Secondary

Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale

The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome.

Posted

Mean

Standard Deviation

units on a scale

10 hr post surgery

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Units	Counts
Participants

Secondary

Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale

The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome.

No participants were analyzed for this time point because participants were discharged from hospital at around 10 hours, before this time point would have occurred.

Posted

11 hr post surgery

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Secondary

Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale

The items are scored on a visual analogical scale from 0-10, with 0 being the better outcome.

No participants were analyzed for this time point because participants were discharged from hospital at around 10 hours, before this time point would have occurred.

Posted

12 hr post surgery

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Secondary

Postoperative Pain Control as Assessed by a Numeric Pain Rating Scale

The items are scored on a visual analogical scale from 0-10, with 0 being the better

Patients were not analyzed at postoperative physicians visit.

Posted

Postoperative physicians visit

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Units	Counts

Secondary

Narcotics Use as Assessed by Morphine Equivalents Consumed

morphine equivalents consumed during the entire post-anesthesia care unit (PACU) visit post surgery will be obtained from the All-scripts electronic medical record (EMR) system.

Posted

Mean

Standard Deviation

milligrams (mg)

Entire post-anesthesia care unit (PACU) visit post surgery, PACU range 1 hr to 12 hrs post surgery

ID	Title	Description
OG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer
OG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer

Arm/Groups

ID	Title	Description	Deaths (Affected)	Deaths (At Risk)	Serious Events (Affected)	Serious Events (At Risk)	Other Events (Affected)	Other Events (At Risk)
EG000	Femoral Nerve Blockade	Ultrasound guided FNB (30 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) below the inguinal ligament using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ) with stimulator confirmation. 30 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer	0	38	0	38	16	38
EG001	Adductor Canal Blockade	Ultrasound guided ACB (15 ml of 0.2% ropivacaine with 100 mcg clonidine using a 22-gauge 40 mm ProBloc II insulated needle; Kimberly-Clark, Roswell, Georgia) at the mid-thigh using a high-frequency linear ultrasound transducer (4-12 Hz; Mindray M7; Mindray North America, Mahwah, NJ). 15 ml of 0.2% ropivacaine 100 mcg clonidine High-frequency linear ultrasound transducer	0	40	0	40	11	40

Other Adverse Events

Term	Organ System	Assessment Type	Statistical Information
Anterior Knee Pain	Musculoskeletal and connective tissue disorders	Non-systematic Assessment	EG0007 events7 affected38 at risk EG0018 events8 affected40 at risk
Knee Extension Loss	Musculoskeletal and connective tissue disorders	Non-systematic Assessment	EG0008 events8 affected38 at risk EG0012 events2 affected40 at risk
Deep Vein Thrombosis	Vascular disorders	Non-systematic Assessment	EG0000 events0 affected38 at risk EG0011 events1 affected40 at risk
Reinjury	Musculoskeletal and connective tissue disorders	Non-systematic Assessment	EG0001 events1 affected38 at risk EG0010 events0 affected40 at risk

ID	Term
D007718	Knee Injuries
D007869	Leg Injuries
D014947	Wounds and Injuries

ID	Term
D000077212	Ropivacaine
D003000	Clonidine

ID	Term
D000813	Anilides
D000577	Amides
D009930	Organic Chemicals
D000814	Aniline Compounds
D000588	Amines
D048288	Imidazolines
D007093	Imidazoles
D001393	Azoles
D006573	Heterocyclic Compounds, 1-Ring
D006571	Heterocyclic Compounds