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| Name | Class |
|---|---|
| Business Finland | OTHER |
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The investigators hypothesize that exercise training program guided by virtual augmented reality glasses or by video from computer screen used at home will improve motivation into exercise training and results in superior adherence to exercise training compared to current practice. The primary objectives of this research project are to study the effects of exercise training guidance by novel technology on 1) exercise capacity, 2) adherence to exercise training, 3) changes in cardiac autonomic function and 4) quality of life in acute coronary syndrome (ACS) patients.
The subjects of the study will be recruited from the consecutive series of patients of men and women admitted to Oulu University Hospital due to an acute coronary syndrome (ACS). The study population will be randomized into control group (n=25) and study group (n=25) matched with age and gender. For all subjects, clinical status including quality of life questionnaire, exercise capacity and autonomic function measurements will be performed at baseline and after exercise training. Exercise training program is six months for both groups according to current guidelines. All the patients will have a detailed and personalized training prescription. Study group will have virtual augmented reality glasses or computer with training video to motivate and control exercise training prescription at home.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Current guidelines rehabilitation | Active Comparator | Exercise rehabilitation at home according to current guidelines. Training is guided and controlled by diary. |
|
| Mobile device guided rehabilitation | Experimental | Exercise rehabilitation at home according to current guidelines. Training is guided and controlled by virtual augmented reality glasses or by mobile device. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Current guidelines rehabilitation | Behavioral | Exercise training intervention is six months and includes four to five aerobic and two strength training session a week according to American Heart Association guidelines for coronary artery disease patients. All the patients will have a detailed and personalized training diary. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in exercise capacity | Change in maximal load during exercise stress test (metabolic equivalents) | Six months (baseline and 6 months) |
| Measure | Description | Time Frame |
|---|---|---|
| Adherence to exercise rehabilitation | Realized training in relation to prescribed training over six months | Weekly from baseline to six months |
| Change in the standard deviation of normal to normal intervals (SDNN) of heart rate variability |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mikko P Tulppo, PhD | University of Oulu | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Oulu | Oulu | 90014 | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41335527 | Derived | Roiha E, Perkiomaki J, Kiviniemi AM, Junttila J, Huikuri HV, Tulppo MP. Individual exercise training response and ECG morphology in patients after an acute coronary syndrome. Physiol Rep. 2025 Dec;13(23):e70687. doi: 10.14814/phy2.70687. | |
| 38343424 | Derived | Saarikoski EO, Roiha ETM, Kiviniemi AM, Cerdan-De-Las-Heras J, Perkiomaki J, Kaikkonen KS, Tulppo MP. Adherence to exercise after an acute coronary syndrome: a 6-month randomized controlled trial. Front Physiol. 2024 Jan 26;15:1319907. doi: 10.3389/fphys.2024.1319907. eCollection 2024. |
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| ID | Term |
|---|---|
| D010349 | Patient Compliance |
| ID | Term |
|---|---|
| D010342 | Patient Acceptance of Health Care |
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |
| D001519 | Behavior |
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| Mobile device guided rehabilitation | Behavioral | Exercise training intervention is six months and includes four to five aerobic and two strength training session a week according to American Heart Association guidelines for coronary artery disease patients. Study group will have virtual glasses or mobile device to motivate and control exercise training program. |
|
Change in 24 h SDNN (ms)
| Six months (baseline and 6 months) |
| Change in very low frequency (VLF) of heart rate variability | Change in 24 h VLF (ms^2) | Six months (baseline and 6 months) |
| Change in low frequency (LF) of heart rate variability | Change in 24 h LF (ms^2) | Six months (baseline and 6 months) |
| Change in high frequency (HF) of heart rate variability | Change in 24 h HF (ms^2) | Six months (baseline and 6 months) |
| Change in fractal scaling exponent of heart rate variability | Change in 24 h Fractal scaling exponent (a.u.) | Six months (baseline and 6 months) |
| Change in baroreflex sensitivity | Change in spontaneous baroreflex sensitivity by cross-spectral method (ms/mmHg) | Six months (baseline and 6 months) |
| Change in quality of life | Change in quality of life measured by 15-D questionaire | Six months (baseline and 6 months) |
| 34741536 | Derived | Dibben G, Faulkner J, Oldridge N, Rees K, Thompson DR, Zwisler AD, Taylor RS. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev. 2021 Nov 6;11(11):CD001800. doi: 10.1002/14651858.CD001800.pub4. |