To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length。

Inclusion Criteria:

• Non-cardiac surgery patients;

  • Age is greater than or equal to 65 years old;

    • Han Nationality, mother tongue is chinese;

      ④The MMSE score:Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points;

      ⑤The Geriatric Depression Scale (GDS) grade 1 or 2;

      ⑥The important function without serious heart, brain, liver, kidney, lung and other organs;

      • The ASA class I or II;

        • The people signed informed consent.

Exclusion Criteria:

• The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.; ②Had severe head and face disease, trauma history or history of surgery;

  • Had a history of influenza in 3 weeks; ④The serious body disease and tobacco, wine and other substance abuse history; ⑤The presence of malignant tumor with shorter survival disease.

We included 1000 Male and female patients undergoing non-cardiac surgery and 50 healthy volunteers at the affiliated hospital of Xuzhou Medical University.