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To ascertain the possibilities to isolate the breast cancer olfactive signature.
Patient recruitment during the first surgery consultation in Curie Institute. Odor sampling (non-invasive) with an odor-sensing polymer (Sorbstar® polymer developed especially for the trace level analysis), on:
Each patient will be her own witness, before and after surgical excision, in an attempt to isolate the chemical signature tracks of breast cancer. The samples after surgery will be made after healing and before implementation of a treatment (chemotherapy and / or radiotherapy).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sorbstar® | Experimental | Odour sampling: Rub hands with Sorbstar® before and post-surgery |
|
| Dog detection | Experimental | Odour sampling: Sleep over a night with a compress on the affected breast before and after surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sorbstar® | Diagnostic Test | Thermodesorption method coupled with full two-dimensional gas chromatography and mass spectrometry. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Ascertain breast cancer olfactive signature (Isolation of volatile Organic Compounds to breast cancer by a sensitive technique with an odor-sensing polymer (Sorbstar®) | Isolation of volatile Organic Compounds to breast cancer by a sensitive technique with an odor-sensing polymer (Sorbstar®) on hands. Friction of the hands according to the protocol before and after surgical excision of the tumor. Sorbstar® analyses will be performed with a thermodesorption method coupled with full two-dimensional gas chromatography and mass spectrometry. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Ascertain breast cancer olfactive signature from the tumor (Isolation of volatile Organic Compounds to tumor breast samples by a sensitive technique with an odor-sensing polymer (Sorbstar®). | During the surgical procedure an odor-sensing polymer (Sorbstar®) over the tumor is placed. Sorbstar® analyzes will be performed with a thermodesorption method coupled with full two-dimensional gas chromatography and mass spectrometry. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Roman ROUZIER, Phd | Institut Curie | Principal Investigator |
| Isabelle FROMANTIN, Phd, IDE | Institut Curie | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| INSTITUT CURIE - Site de Saint Cloud | Saint-Cloud | 92210 | France |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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Interventional, prospective, open, monocentric study with risks and minimal constraints
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| Odour sampling | Diagnostic Test | Analyzed by the dogs of Curie Institute at the training centers |
|
| 13 months |
| Ascertain breast cancer detection by the dogs of Curie Institut | Patients sleep over a night with a compress positioned on the affected breast before and after surgery. The compress will be analyzed by the dogs of Curie Institut (results cancer/not cancer). | 13 months |
| D017437 |
| Skin and Connective Tissue Diseases |