Isolation of Volatile Organic Compounds (VOCs) Related to the Olfactory Signature of Breast Cancer

Feasibility Study on the Possibility of Isolation of Volatile Organic Compounds (VOCs) Related to the Olfactory Signature of Breast Cancer

To ascertain the possibilities to isolate the breast cancer olfactive signature.

Patient recruitment during the first surgery consultation in Curie Institute. Odor sampling (non-invasive) with an odor-sensing polymer (Sorbstar® polymer developed especially for the trace level analysis), on:

• The hands, before and after surgical excision of the tumor (friction of the hands)
• The diseased breast, before and after surgical excision of the tumor (via a compress positioned on the breast for 1 night)
• The tumor, during the surgical procedure (odor collection over a tumor sample).

Each patient will be her own witness, before and after surgical excision, in an attempt to isolate the chemical signature tracks of breast cancer. The samples after surgery will be made after healing and before implementation of a treatment (chemotherapy and / or radiotherapy).

Inclusion Criteria:

1. Patient received in surgery consultation for an invasive non metastatic breast cancer treated by breast-conserving surgery with axillary or sentinel node dissection
2. Of-Age female patient (over 18 years old)
3. Life expectancy > to 1 year at the inclusion
4. Performance status: 0 or 1 or 2
5. Patient benefiting from the social security
6. Signature informed consent of the study

Exclusion Criteria:

1. Neoplasia in progress or neoplasia history of cancer other than breast to be treated.
2. Wound presence on breasts
3. Male subjects
4. Specified metastatic breast cancer
5. Concomitant medication taken one month before the surgical act (antibiotics, corticoids, anti-diabetics)
6. Persons under guardianship or deprived of liberty
7. Impossibility to submit to the medical monitoring expected by the study for geographical, social or psychological reasons.