Protective Effect of Tranexamic Acid on Shedding of the Endothelial Glycocalyx in Patients Undergoing Spinal Fusion Surgery

Protective Effect of Tranexamic Acid on Shedding of the Endothelial Glycocalyx in Patients Undergoing Spinal Fusion Surgery

The aim of this study was to determine whether the administration of tranexamic acid in patients undergoing lumbar spinal fusion surgery can inhibit damage in endothelial glycocalyx layer. As a prospective double blinded randomized placebo-controlled trial, the investigators detect and compare the changes in concentrations of serum syndecan-1 and heparan sulfate before and after surgery.

Inclusion Criteria:

• Adult patients with between 30 and 80 years scheduled for posterior lumbar spinal fusion surgery.

Exclusion Criteria:

• emergency surgery
• patients unable to make their own decisions, illiterate, foreigners
• Allergy / hypersensitivity to Tranexamic acid
• Current or past history or thrombosis / thromboembolism
• patients who are taking oral contraceptives
• Patients with renal insufficiency (eGFR 60 ml / min / 1.73 m 2 or less)
• Patients receiving anticoagulants
• pregnant and lactating women