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This study evaluates the impact of local anesthetic administration regiment through peri-neural femoral nerve catheter on pain and motor block frequency, after total knee arthroplasty.
This study evaluates the impact of local anesthetic administration regiment through peri-neural femoral nerve catheter on pain and motor block frequency, after total knee arthroplasty. One group of patients will receive automated intermittent bolus, while the others will get a continuous infusion. In both cases, patients will be able to administer supplementary auto-bolus if required.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Continous infusion ropivacaine | Active Comparator | Continuous infusion via peri-neural femoral nerve catheter of Ropivacaine Hcl 0.2% Inj Bag 200Ml (CI mode) at rate of 6ml/h + patient controlled bolus of 3ml ... |
|
| PIB ropivacaine | Experimental | Programmed intermittent bolus of Ropivacaine Hcl 0.2% Inj Bag 200Ml (PIB mode) : 6ml each 60min + patient controlled bolus 3ml ... |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ropivacaine Hcl 0.2% Inj Bag 200Ml (PIB mode) | Drug | programmed intermittent bolus 5ml each one hour. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Frequency of unplanned analgesia interventions. | Composite criteria including the frequency of unplanned analgesia interventions administered by the patient, or paramedical and medical staff, and by extenstion the total amount of opioids (in milligrams equivalent morphine) and local anesthetics (in milligrams) received in post-operative period. | up to 72 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Pain difference | Pain difference accessed by Numeric Pain Rating Scale (0-10), twice a day, at rest and on movement. | up to 72 hours after surgery |
| Motor block frequency | Accessed by physiotherapist twice a day, by testing the Quadriceps muscle. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Annis Orfi | University of Liege | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Liege | Liège | 4000 | Belgium |
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| Ropivacaine Hcl 0.2% Inj Bag 200Ml (CI mode) | Drug | continuous infusion 6ml/h |
|
|
| up to 72 hours after surgery |
| Mobilization quality during physiotherapy sessions. | accessed by physiotherapist, ability to walk with or without help, take stairs, and flex and extend knee (comparatively to the opposite knee). | up to 72 hours after surgery |
| local anesthesia technique related complications | rate of complications including: hematoma, infection, catheter dislodgement or breakage, allergic events. | until catheter removal 48 hours after surgery |
| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| D011183 | Postoperative Complications |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D000077212 | Ropivacaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |
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