Arterial Oxygen Saturation on Ventilatory Stability in Extremely Premature Infants

Impact of Arterial Oxygen Saturation Range on Ventilatory Stability in Extremely Premature Infants

This is a prospective crossover study to compare the within-subject effect of the two target ranges of arterial oxygen saturation (SpO2), both within the clinically recommended range of 90- 95%. The specific objective of this study to evaluate the impact of targeting SpO2 within 93-95% compared to the 90-92% range on ventilatory stability in premature infants of 23-29 weeks gestational age (GA).

Inclusion Criteria:

• 23 0/7- 29 6/7 weeks gestational age
• Postnatal age ≥ 14 days
• Requiring FiO2 ≥ 0.25 to keep SpO2 90-95%
• Parental informed consent

Exclusion Criteria:

• Severe congenital anomalies that may affect pulmonary or neurosensory development
• Severe CNS pathology that may alter respiratory control function