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I did not pass the 2018 Ministry of Science and Technology research project subsidy, so I applied for the project to close the case.
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We will get the impact of mirabegron on psychological distress, urethra and bladder blood flow and c reactive protein.
Background/Purpose: Pharmacologic treatments for female overactive bladder syndrome (OAB) include antimuscarinics and beta-agonist. Similar efficacy has been reported between antimuscarinics and beta-agonist. Antimuscarinics has been found to be beneficial for patients with psychological distress. However, the impact of mirabegron on psychological distress in female OAB remains unknown. In addition, some animal studies found that beta-3 agonist can improve arterial blood flow, bladder ischemia and might improve bladder function; however, there is still lack of human study. Besides, c reactive protein was found to be elevated in female OAB. Nonetheless there is no study mentioning about the impact of mirabegron on c reactive protein. Thus, the aim of this study is to elucidate the impact of mirabegron on psychological distress, bladder blood flow and c reactive protein.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mirabegron | Experimental | OAB female patients who will receive beta-3 agonist (mirabegron 2 mg) treatment |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mirabegron 25mg | Drug | The aim of this study is to elucidate the impact of mirabegron on psychological distress, bladder blood flow and c reactive protein. |
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| Measure | Description | Time Frame |
|---|---|---|
| Brief symptom rating scale | The Brief symptom rating scale (BSRS) includes the following dimensions of psychopathology: somatic symptoms, obsessive-compulsive symptoms, interpersonal sensitivity, depressive symptoms, anxiety symptoms, hostility, phobic-anxiety, and paranoid tendency. Additional symptoms include vegetative and other clinical indicators. The BSRS is composed of 30 items rated on the basis of degree of distress caused by that item over the past week. Each dimension is assessed by several questions with a 5-point Likert scale (0-4 points). The severity of a psychopathologic factor is expressed with an index calculated from the sum of scores divided by the number of questions in that specific dimension. The General Symptom Index (GSI), a mean score of all BSRS items, represents the global severity of psychological distress (PD), and a higher GSI indicates more severe PD. The BSRS has been reported to be a reliable and valid psychiatric self-rating scale for use in psychosomatic research. | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Bladder wall blood flow | vascularization index (VI) 、flow index (FI) and vascularization flow index (VFI) | 12 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Far Eastern Memorial Hospital | Banqiao District | New Taipei | 22050 | Taiwan |
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| ID | Term |
|---|---|
| C520025 | mirabegron |
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