Probiotic and Influenza Vaccination to Reducing Influenza-like Illness Incident in Elderly

Role of Probiotic and Influenza Vaccination on Immune Response Enchancement and Influenza-Like Illness Incidence Reduction in Elderly

To asses the effect of the probiotic and influenza vaccination alone and combination on enhancing immune response to influenza-like illness (ILI) and reducing ILI incidence in the elderly

To see percetange of subjects seroconvertion and seroprotection before and after intervention in the elderly (>60 years), and monitored for 6 months.

Inclusion Criteria:

• all health elderly aged ≥ 60 years
• who came to the vaccination and health education activities in the entire East Jakarta District Health Center
• with Body Mass Index (BMI) 17,5-29,9
• healthy mental status (MMSE score of 28-30)

Exclusion Criteria:

• subject who have contraindications to influenza vaccinations
• are undergoing treatment related to immune system modulation in the past 4 weeks
• therapy for immunossuppresants and/ or corticosteroids eqivalent to prednisone ≥ 20 mg/day that is being lived more than 2 weeks or has only been stopped less than 3 months before the study
• recieved influenza vaccination less than one year before
• Currently consuming probiotic agents, either in the form of a manufacturer or natural for more than 7 days.