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| Name | Class |
|---|---|
| Swiss Federal Institute of Technology in Zurich (ETH Zurich) | UNKNOWN |
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The aim of this project is to investigate whether enhancing sleep intensity locally in the prefrontal cortex (PFC) can counteract a deterioration of cognitive control and therefore the previously described increase in risk seeking during chronic sleep restriction. To this end, a controlled, counter-balanced study, consisting of two weeks of sleep restriction will be performed. During one of the sleep restriction weeks, sleep intensity in the PFC will be non-invasively enhanced by acoustic stimulation of slow waves during sleep.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sleep restriction without acoustic stimulation | Sham Comparator |
| |
| Sleep restriction with acoustic stimulation | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sleep restriction | Behavioral | Time in bed will be restricted to 5 hours per night for 7 nights. |
|
| Measure | Description | Time Frame |
|---|---|---|
| risk-premium | risk-preference (i.e. risk premium assessed with the risk Task as described in Maric et al. 2017 Ann Neurol) after chronic sleep restriction with and without acoustic Stimulation will be quantified by the risk-premium derived from the choices made in the risk-task as described in Maric et al. 2017 Ann Neurol. | comparison of change from baseline after 7 nights of sleep restriction with acoustic stimulation to change from baseline after 7 nights of sleep restriction without acoustic stimulation |
| Measure | Description | Time Frame |
|---|---|---|
| high-density electroencephalography (hdEEG) marker of sleep pressure | Slow wave activity (SWA) assessed by hd-EEG with 128 electrodes | assessed during first and last sleep restriction nights in comparison to baseline values |
| brain metabolites |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Zurich | Zurich | Canton of Zurich | 8091 | Switzerland |
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| ID | Term |
|---|---|
| D000161 | Acoustic Stimulation |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D026421 | Sensory Art Therapies |
| D000529 | Complementary Therapies |
| D010812 | Physical Stimulation |
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| Acoustic stimulation | Other | Brief tones will be presented time-locked to ongoing slow waves during deep sleep. |
|
Glutamate and gamma-aminobutyric acid (GABA) concentration in the right prefrontal Cortex assessed by magnetic resonance (MR) spectroscopy
| before to after 7 nights of sleep restriction with and without acoustic stimulation |
| vigilance measures | Performance impairments in the psychomotor-vigilance task | before to after 7 nights of sleep restriction with and without acoustic stimulation |
| deception willingness | deception willingness measured by the willingness to deception of outcome in a card game with binary outcome (win and loss) | before to after 7 nights of sleep restriction with and without acoustic stimulation |
| Motor inhibitory control performance | inhibitory control performance measured by the stop-signal-task. | before to after 7 nights of sleep restriction with and without acoustic stimulation |
| confidence | overconfidence measured by an incentivised procedure that elicits the certainity equivalent of a bet based on Performance in a quiz (cf. Murad et al. 2016 J Risk Uncertain) | before to after 7 nights of sleep restriction with and without acoustic stimulation |
| overconfidence | overconfidence measured by an incentivised procedure that elicits the certainity equivalent of a bet based on Performance in a quiz (cf. Murad et al. 2016 J Risk Uncertain) | before to after 7 nights of sleep restriction with and without acoustic stimulation |
| impulsivity | impulsivity as measured by an intertemporal choice Task. | before to after 7 nights of sleep restriction with and without acoustic stimulation |
| Ocular inhibitory control performance | Ocular inhibitory control Performance measured by the Anti-Saccade Task. | before to after 7 nights of sleep restriction with and without acoustic stimulation |
| Effort in inhibitory control performance | Pupil response (i.e. dilation) during a simple Go/No-Go Task. | before to after 7 nights of sleep restriction with and without acoustic stimulation |
| Excessive daytime sleepiness | Excessive daytime sleepiness assessed by the Epworth sleepiness scale and the Stanford Sleepiness Scale. | before to after 7 nights of sleep restriction with and without acoustic stimulation |
| D008919 |
| Investigative Techniques |