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| Name | Class |
|---|---|
| GeneCast Biotechnology Co., Ltd. | INDUSTRY |
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In order to understand the efficacy and side effects of lung cancer immunotherapy, at least 30 patients with lung cancer who were treated with immunotherapy were enrolled. The second-generation sequencing technology and liquid phase factor platform were used for detection, and clinical imaging and other evaluation methods were used to explore the immunotherapy efficacy and side effects affecting lung cancer。
In order to understand the efficacy and side effects of lung cancer immunotherapy, at least 30 patients with lung cancer who were treated with immunotherapy were enrolled. The second-generation sequencing technology and liquid phase factor platform were used for detection, and clinical imaging and other evaluation methods were used to explore the immunotherapy efficacy and side effects affecting lung cancer。
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| immunotherapy effective group | PD1, TMB and serum cytokines was detected before nivolumab treatment | ||
| immunotherapy ineffective group | PD1, TMB and serum cytokines was detected before nivolumab treatment |
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| Measure | Description | Time Frame |
|---|---|---|
| PD-L1 expression levels | The positive rate of PD-L1 expression in tumor tissues was detected by immunohistochemistry | before drugs thearpy |
| PD-1 expression levels | The positive rate of PD-L1 expression in tumor tissues was detected by immunohistochemistry | before drugs thearpy |
| tumor mutation burden | Detection of the average number of mutations per megabyte in tumor tissues by NGS | before drugs thearpy |
| Serum cytokine levels | Detect the expression level of cytokines in serum | before drugs thearpy |
| Objective Response Rate (ORR) by irRC and RECIST 1.1 | 6 months | |
| Number of participants with treatment-related adverse events as assessed by CTCAE v4.0 | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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advance lung cancer
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University | Recruiting | Guangzhou | Guangdong | 510120 | China |
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| ID | Term |
|---|---|
| D002289 | Carcinoma, Non-Small-Cell Lung |
| ID | Term |
|---|---|
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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