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This study aimed to compare teriparatide treatments and PVPs, focusing on its effects on life qualities and effect/coast ratio and evaluate which method is better for patients.
Osteoporosis and osteoporotic vertebral fracture (OVF)s are the common diseases that affect the qualities of senior people. The general treatments for OVFs including percutaneous vertebroplasty (PVP) operation and conservative treatments with pain killers. But with the widely used methods, the life quality of patients were still not satisfied. Teriparatide has been proven to increase bone qualities in patients with severe osteoporosis and reduced the fracture possibilities. The investigators' previous clinical observation found teriparatide could be applied to treat fresh OVFs.
90 participants who diagnosed fresh OVFS were included in the trial. After they received each of three kinds of interventions mentioned in this study, The investigators followed up all these cases. Once 30 cases goal reaches in a certain group, the data collection in that special will stop automatically. The quality of life, pain score and BMDs will be evaluated in certain time during the trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| teriparatide group | The group of postmenopausal women who diagnosis with osteoporotic fractures treated with teriparatide |
| |
| PVP group plus alendronate | The group of postmenopausal women who diagnosis with osteoporotic fractures treated with vertebroplasty. Then alendronate was prescribed. |
| |
| teriparatide and PVP group | The group of postmenopausal women who diagnosis with osteoporotic fractures treated with teriparatide after vertebroplasty |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Teriparatide | Drug | subcutaneous injection of teriparatide(20 mg) once daily |
|
| Measure | Description | Time Frame |
|---|---|---|
| Quality of life of the patients | The quality of life will be evaluated with SF-36 questionaire | Change from pre treatment at 3 months, 6 months, 1 year and 2 years post treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Pain cause by the fracture | VAS score will be used to evaluate the pain caused by OVF | Change from pre treatment at 3 months, 6 months, 1 year and 2 years post treatment |
| Bone healing | Bone healing will be evaluated with MRI scanning |
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Inclusion Criteria:
Exclusion Criteria:
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postmenopaual women with osteoporotic vertebral fractures, reveived treatments with teriparatide, PVP, teriparatide after PVP, or fosamax only.
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| Name | Affiliation | Role |
|---|---|---|
| Dehong Yang, MD,PhD | Nanfang Hospital, Southern Medical University | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41163205 | Derived | Xie Y, Niu S, Ma Y, Liao Y, Zhu Y, Feng L, Zheng M, Yang D. Sequential anti-osteoporotic therapy with teriparatide and alendronate optimizes outcomes of percutaneous vertebroplasty in acute osteoporotic vertebral fractures: a 12-month prospective cohort study. BMC Musculoskelet Disord. 2025 Oct 29;26(1):1011. doi: 10.1186/s12891-025-09256-w. |
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| ID | Term |
|---|---|
| D015663 | Osteoporosis, Postmenopausal |
| D016103 | Spinal Fractures |
| ID | Term |
|---|---|
| D010024 | Osteoporosis |
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| D019379 | Teriparatide |
| D019386 | Alendronate |
| ID | Term |
|---|---|
| D010281 | Parathyroid Hormone |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
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| PVP | Procedure | With local anesthesia, bone cement was injected in to fractured body in a needle that penetrated transpedically and percutaneously |
|
| Alendronate | Drug | Alendronate Sodium, oral, 70mg, once a week |
|
| 3 month after treatment |
| Bone mineral density | Bone mineral density will be evaluated with DEXA. | Change from pre treatment at 6 months, 1 year and 2 years post treatment |
| D008659 |
| Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D013124 | Spinal Injuries |
| D019567 | Back Injuries |
| D014947 | Wounds and Injuries |
| D050723 | Fractures, Bone |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D004164 | Diphosphonates |
| D063065 | Organophosphonates |
| D009943 | Organophosphorus Compounds |
| D009930 | Organic Chemicals |