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| Name | Class |
|---|---|
| Hospital Universitari Vall d'Hebron (Drassanes) | UNKNOWN |
| Servicios Clínicos de Barcelona | UNKNOWN |
| Germans Trias i Pujol Hospital | OTHER |
| Hospital Sant Joan de Deu |
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Tuberculosis is a chronic infectious disease that affects 10 million people, 300 in the city of Barcelona, every year. With serious consequences at public health level, it is associated with other diseases, and generated and influenced by many social and psychological factors. This study aims to stage tuberculosis disease by an integrative approach.
Tuberculosis is a chronic infectious disease that affects 10 million people, there are 300 new cases 300 in the city of Barcelona, every year. Tuberculosis has serious consequences at public health level. It is associated with other diseases, and generated and influenced by many social and psychological factors. This study aims to stage tuberculosis disease by a novel integrative approach.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TB patients | TB patients diagnosed and followed-up in Barcelona, at the following Hospitals/Clinics: Servicios Clínicos, Hospital Universitari Germans Trias i Pujol, Hospital Universitari Vall d'Hebron-Drassanes, Hospital del Mar. |
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| Measure | Description | Time Frame |
|---|---|---|
| Clinical changes | Changes in clinical status | timepoints 0 (at inclusion), at month 2 and month 6 (and month 12 if MDR/XDR) |
| Microbiological changes | Changes in microbiological cultures | timepoints 0 (at inclusion), at month 2 and month 6 (and month 12 if MDR/XDR) |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Biomarkers values | Changes in the biomarkers along time assessed by using analyzing parameters in blood and urine samples (by ELISA and LUMINEX) | timepoints 0 (at inclusion), at month 2 and month 6 (and month 12 if MDR/XDR) |
| Radiological Score Value |
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Inclusion Criteria:
Exclusion Criteria:
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TB patients which clinical management is done at the following clinical centers: Servicios Clínicos, Hospital Universitari Vall d'Hebron-Drassanes or Hospital Universitari Germans Trias i Pujol.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Cris Vilaplana, MD, PhD | Contact | 934978677 | cvilaplana@gmail.com | |
| Laura Villegas | Contact | +34934978681 | secretary.ute@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Cris Vilaplana, MD, PhD | Fundació Institut Germans Trias i Pujol | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Universitari Germans Trias i Pujol | Recruiting | Badalona | Barcelona | 08916 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38349459 | Background | Romero-Tamarit A, Valles X, Munar-Garcia M, Espinosa-Pereiro J, Saborit N, Tortola MT, Stojanovic Z, Roure S, Antuori A, Cardona PJ, Soriano-Arandes A, Martin-Nalda A, Espiau M, de Souza-Galvao ML, Jimenez MA, Noguera-Julian A, Molina I, Casas X, Dominguez-Alvarez M, Jove N, Gogichadze N, L Fonseca K, Arias L, Millet JP, Sanchez-Montalva A, Vilaplana C. A longitudinal prospective study of active tuberculosis in a Western Europe setting: insights and findings. Infection. 2024 Apr;52(2):611-623. doi: 10.1007/s15010-024-02184-2. Epub 2024 Feb 13. | |
| 37275492 |
| Label | URL |
|---|---|
| Institutional webpage- Experimental TB Unit | View source |
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IPD that underlie results in a publication might be shared with other researchers
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| ID | Term |
|---|---|
| D014376 | Tuberculosis |
| D003141 | Communicable Diseases |
| ID | Term |
|---|---|
| D009164 | Mycobacterium Infections |
| D000193 | Actinomycetales Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
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| OTHER |
| Hospital del Mar | OTHER |
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Bloood samples for determination of DNA
Changes in the BCN-SA Radiological Score Value. This Score assesses the sum of acute and chronic findings in the chest X-ray. Per each finding, a maximum score of 8 is recorded. The total score value is calculated by adding all the individual findings score values. Higher values of total score represent a worse outcome. |
| timepoints 0 (at inclusion), at month 2 and month 6 (and month 12 if MDR/XDR) |
| Changes in SGRQ score | Changes in Health Quality of Life measures along time assessed by using the Saint George's Respiratory Questionnaire (SGRQ, numeric score). It measures 3 subscales (symptoms/activity/impacts) and The Total score is calculated by summing all positive responses in the questionnaire and expressing the result as a percentage of the total weight for the questionnaire. Higher values represent a worse outcome. | timepoints 0 (at inclusion), at month 2 and month 6 (and month 12 if MDR/XDR) |
| Changes in Kessler-10 score | Changes in Health Quality of Life measures along time assessed by using the questionnaire Kessler-10 (K10, numeric score). Higher values represent a worse outcome. | timepoints 0 (at inclusion), at month 2 and month 6 (and month 12 if MDR/XDR) |
| Changes in Health Quality of Life measures along time using BCN-Q questionnaire | Changes in Health Quality of Life measures along time using BCN-Q questionnaire (descriptive questionnaire). | timepoints 0 (at inclusion), at month 2 and month 6 (and month 12 if MDR/XDR) |
| Hospital Sant Joan de Déu | Recruiting | Esplugues de Llobregat | Barcelona | 08950 | Spain |
|
| Hospital del Mar | Recruiting | Barcelona | 08003 | Spain |
|
| Hospital Universitari Vall d'Hebron-Drassanes | Recruiting | Barcelona | Spain |
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| Servicios Clínicos de Barcelona | Recruiting | Barcelona | Spain |
|
| Background |
| Roure S, Valles X, Sopena N, Benitez RM, Reynaga EA, Bracke C, Loste C, Mateu L, Antuori A, Baena T, Portela G, Llussa J, Flamarich C, Soldevila L, Tenesa M, Perez R, Plasencia E, Bechini J, Pedro-Botet ML, Clotet B, Vilaplana C. Disseminated tuberculosis and diagnosis delay during the COVID-19 era in a Western European country: a case series analysis. Front Public Health. 2023 May 18;11:1175482. doi: 10.3389/fpubh.2023.1175482. eCollection 2023. |
| 31850353 | Result | Pujol-Cruells A, Vilaplana C. Specific Interventions for Implementing a Patient-Centered Approach to TB Care in Low-Incidence Cities. Front Med (Lausanne). 2019 Nov 26;6:273. doi: 10.3389/fmed.2019.00273. eCollection 2019. |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |