In France, one in 4500 women is affected by the MayerRokitantskyKüsterHauser (MRKH) syndrome which is characterized by the absence of uterus at birth. Currently, the only solutions for these patients are:

• Gestational surrogacy, prohibited in France
• Adoption
• Resignation

Uterine transplantation could become a good alternative.

This study is conducted in 10 patients with MRKH type I syndrome, who will be transplanted from a living donor uterus

The aim of the study is to obtain a pregnancy after uterine transplantation from a living donor. Also, this study will assess (anatomically and functionally) the issue of the transplants of a uterus taken from a living donor and the safety of the living donor (functionally and psychologically)

Inclusion Criteria:

Graft recipient is a patient with Mayer-Rokitansky-Küster-Hauser Type I Uterine Vaginal Agenesis (without renal, cardiac and bone malformations):

• Being aged between 18 and 38 years old
• In stable couple, with a pregnancy project, favorable psychological evaluation
• No history of cancer and transfusion

The living donor is a woman related to the Graft recipient with

• Absence of comorbidity (neurological, nephro-urological pathology, infectious, psychiatric or psychological pathology)
• Absence of uterine surgery, abdomino-pelvic major pathology history

Exclusion Criteria:

Graft recipient:

• Extreme oligo-astheno-spermia and azoospermia in the husband
• History of abdominopelvic surgery excluding uncomplicated appendectomy; vaginal residue not allowing anastomosis

Living donor :

• Known thromboembolic risk factor
• No Compatibility with the recipient (group, rhesus, HLA)