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Spinocerebellar atrophy is the most common autosomal dominant inherited ataxia. There are over thirty subtypes, which characterize neurologic features differently. They all have obvious substantial cerebellar atrophies in image, and unstable gait、ataxia. In general a prevalence of about three cases per 100 000 people is assumed, but this may be an underestimate. Progressive neurologic degeneration, in about 10-20 years, will leads to disability or wheelchair-dependent. Accompanying with fatigue, downhill course of the disease often made patients depressive and hopeless. The recent review of researches concludes no effective therapy for the disease. The purpose of the investigator's study is to explore the Tai-chi exercise effect for spinocerebellar ataxia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tai chi | Experimental | participants in this group accepted Tai chi exercise and conventional medicine. |
|
| controlled group | Active Comparator | participants were not received Tai chi exercise, but only routine conventional medicine |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tai chi | Behavioral | participants were required to receive hospital-based Tai chi training at least once a month, and home-based Tai chi exercise at least three times a week over the next 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| Scale for the Assessment and Rating of Ataxia(SARA) | SARA assesses eight aspects of cerebellar function: walking, sitting, standing, speaking, finger chasing, the nose-finger test, fast alternating hand movements, and the heel-shin slide. The eight categories accumulate score ranging from 0 (no ataxia) to 40 (most severe ataxia).Gait (0-8 points),Stance (0-6 points),Sitting (0-4 points),Speech disturbance (0-6 points),Finger chase (0-4 points),Nose-finger test (0-4 points),Fast alternating hand movement (0-4 points),Heel-shin slide (0-4 points) | assessed at baseline and 9 months, 9 months reported as Outcome Measure Data |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lun-Chien Lo | Director of Chinese Medicine | Principal Investigator |
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| ID | Title | Description |
|---|---|---|
| FG000 | Tai Chi | participants in this group accepted Tai chi exercise and conventional medicine. Tai chi: participants were required to receive hospital-based Tai chi training at least once a month, and home-based Tai chi exercise at least three times a week over the next 9 months conventional medicine: participants without Tai chi training still received routine conventional medicine |
| FG001 | Controlled Group | participants were not received Tai chi exercise, but only routine conventional medicine conventional medicine: participants without Tai chi training still received routine conventional medicine |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Tai Chi | Subjects accepted Tai Chi exercise once a week in the hospital, and home-based training with a video. |
| BG001 | Controlled Group | No Tai Chi training. Only regular out-patient clinic visiting. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Median |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Scale for the Assessment and Rating of Ataxia(SARA) | SARA assesses eight aspects of cerebellar function: walking, sitting, standing, speaking, finger chasing, the nose-finger test, fast alternating hand movements, and the heel-shin slide. The eight categories accumulate score ranging from 0 (no ataxia) to 40 (most severe ataxia).Gait (0-8 points),Stance (0-6 points),Sitting (0-4 points),Speech disturbance (0-6 points),Finger chase (0-4 points),Nose-finger test (0-4 points),Fast alternating hand movement (0-4 points),Heel-shin slide (0-4 points) | Posted | Median | Inter-Quartile Range | score on a scale | assessed at baseline and 9 months, 9 months reported as Outcome Measure Data |
|
9 months
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Tai Chi | Participants were required to receive hospital-based Tai chi training at least once a month, and home-based Tai chi exercise at least three times a week over the next 9 months |
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There were insufficient case numbers in this study, in both groups. There were patients with different gene types, non-hereditary, or even multiple system atrophy in the recruited subjects.
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Chung-Min Chiu | Changhua Christian Hospital | *886-982-506-067 | shongdiah@gmail.com |
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| ID | Term |
|---|---|
| D020754 | Spinocerebellar Ataxias |
| ID | Term |
|---|---|
| D002524 | Cerebellar Ataxia |
| D002526 | Cerebellar Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D026302 | Tai Ji |
| ID | Term |
|---|---|
| D026441 | Mind-Body Therapies |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D026241 | Exercise Movement Techniques |
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| conventional medicine | Drug | participants without Tai chi training still received routine conventional medicine |
|
| BG002 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| scale for assessment and rating of ataxia | Scale for assessment and rating of ataxia (SARA) is used to assess patients of ataxia worldwide. It contains eight aspects, including gait, standing, sitting, finger-nose-finger test, heel to shin, and etc.. It is also an appropriate measure tool for longitudinal assessment of disease progression. The score ranges from 0 to 40 points, while higher points means worse ataxia. | Median | Inter-Quartile Range | units on a scale |
|
| OG001 |
| Controlled Group |
No Tai Chi training. Only regular out-patient clinic visiting. We measured the SARA before and after the nine months. |
|
|
| 0 |
| 12 |
| 0 |
| 12 |
| 0 |
| 12 |
| EG001 | Controlled Group | Participants without Tai chi training still received routine conventional medicine | 0 | 9 | 0 | 9 | 0 | 9 |
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| D009422 |
| Nervous System Diseases |
| D013132 | Spinocerebellar Degenerations |
| D013118 | Spinal Cord Diseases |
| D020271 | Heredodegenerative Disorders, Nervous System |
| D019636 | Neurodegenerative Diseases |
| D001259 | Ataxia |
| D020820 | Dyskinesias |
| D009461 | Neurologic Manifestations |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D026741 |
| Physical Therapy Modalities |