Comparison of Balanced Crystalloids and Normal Saline in Septic Patients

Comparison of Balanced Crystalloids and Normal Saline in Septic Patients

In this prospective randomized controlled trial, investigators attempt to study the effects of acetated Ringer's solution on the prognosis and renal function of patients with sepsis in intensive care unit compared with normal saline, and provide evidence for current fluid resuscitation strategies for sepsis.

During the study period，either normal saline or acetated Ringer's solution will be assigned as resuscitation fluid to the septic patients meeting the inclusion criteria.It is anticipated that about 500 patients will be enrolled during the study period.

Inclusion Criteria:

• Patients diagnosed sepsis aged 18~75 and accepted therapy in ICU

Exclusion Criteria:

• Need of Renal replacement treatment
• End-stage renal failure
• pregnant woman