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| Name | Class |
|---|---|
| Wu Jieping Medical Foundation | OTHER |
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In this prospective randomized controlled trial, investigators attempt to study the effects of acetated Ringer's solution on the prognosis and renal function of patients with sepsis in intensive care unit compared with normal saline, and provide evidence for current fluid resuscitation strategies for sepsis.
During the study period，either normal saline or acetated Ringer's solution will be assigned as resuscitation fluid to the septic patients meeting the inclusion criteria.It is anticipated that about 500 patients will be enrolled during the study period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 0.9% saline | Experimental | We use 0.9% saline for resuscitation fluid in ICU septic patients |
|
| Balanced Crystalloids | Experimental | We use acetated Ringer's solution for resuscitation fluid in ICU septic patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 0.9% saline | Drug | we use 0.9% saline in ICU patients with sepsis for resuscitation fluid. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Development of kidney injury as defined by the KDIGO criteria. | Investigators will use the level of creatinine(μmol/L) and body weight adjusted urine(ml/h/kg) for severity assessment of kidney injury | 5 days after the admission |
| Need of renal replacement treatment | Investigators will assess patients' kidney function everyday | After the admission and before the discharge from ICU,average 15 days |
| Measure | Description | Time Frame |
|---|---|---|
| ICU stay | the time of patients' requirement for critical care | After the admission and before the discharge from ICU,average 15 days |
| 28 days mortality | the short time mortality |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Li He, investigator | Contact | 008617798258617 | helisoul@163.com | |
| Li He | Contact | 008617798258617 | helisoul@163.com |
| Name | Affiliation | Role |
|---|---|---|
| ZhiYong Peng, professor | Zhongnan Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongnan Hospital | Recruiting | Wuhan | Hubei | 434000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38369528 | Derived | Zhang J, Liu F, Wu Z, Jiang J, Wang B, Qian Y, Suo J, Li Y, Peng Z. ACETATE RINGER'S SOLUTION VERSUS NORMAL SALINE SOLUTION IN SEPSIS: A RANDOMIZED, CONTROLLED TRIAL. Shock. 2024 Apr 1;61(4):520-526. doi: 10.1097/SHK.0000000000002324. Epub 2024 Feb 1. | |
| 33494795 | Derived | Liu F, Zhang J, Zhu Y, Su L, Li Y, He L, Yu L, Peng Z. Acetate Ringer's solution versus 0.9% saline for septic patients: study protocol for a multi-center parallel controlled trial. Trials. 2021 Jan 25;22(1):89. doi: 10.1186/s13063-020-05007-5. |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| D058186 | Acute Kidney Injury |
| D012772 | Shock, Septic |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D000077330 | Saline Solution |
| D000077325 | Ringer's Lactate |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
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One model using normal saline for resuscitation fluid,the other using acetated Ringer's solution
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| lactated Ringer's solution | Drug | we use balanced balanced crystalloids in ICU patients with sepsis for resuscitation fluid. |
|
|
| 28 days after the admission in ICU |
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D012769 | Shock |