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Assessment of serum level of glial fibrillary acidic protein (GFAP) before surgery (on the day of surgery), 24 hours after surgery and on 3 or 4 postoperative day. Neuropsychological testing before surgery and on 3 or 4 day after surgery. Investigation of relationship between changes of GFAP and scores of neuropsychological tests.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Delayed Neurocognitive decline | Patients in whom there is Delayed Neurocognitive Recovery (DNR) after surgery, based on neuropsychological tests or clinically. DNR is defined as follow: 1)decrease of scores of neuropsychological test scores for more than 1 standard deviation (SD) of these tests; 2)clinically - inability of patient to perform test after surgery because of neurocognitive impairment. |
| |
| Normal postop neurocognitive function | Patients in whom there is no clinical signs of DNR, defined as in previous group. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Glial fibrillary acidic protein | Diagnostic Test | 3 samples of serum are drawn from patients. The 1st Sample of patient serum is drawn before induction into anesthesia. The 2nd is drawn 24 hours after the 1st one. The 3rd sample is drawn on 3 or 4 postoperative day. All samples collected and preserved in the same temperature as required for ELISA. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in serum GFAP | GFAP(3) - GFAP (1); GFAP (2) - GFAP (1) | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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All patients who undergo surgery in Moscow Clinical Scientific Center
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| Name | Affiliation | Role |
|---|---|---|
| Valery Subbotin, Ph.D., M.D. | Moscow Clinical Scintific Center | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Moscow Clinical Scientific Center | Moscow | Moscow | 111123 | Russia |
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| ID | Term |
|---|---|
| D005911 | Gliosis |
| D000079690 | Postoperative Cognitive Complications |
| D000071257 | Emergence Delirium |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011183 | Postoperative Complications |
| D060825 | Cognitive Dysfunction |
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| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D003693 | Delirium |
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |