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To evaluation of nailfold microcirculation in patients with chronic renal failure and its intervention therapy
The aim of this study is to study the changes of Nailfold Microcirculation in patients with chronic renal failure, to clarify the correlation between the changes of Nailfold Microcirculation and renal function, and to explore whether nailfold microcirculation can be used as an indicator of renal microcirculation in patients with chronic renal failure, and to provide a noninvasive method for the clinical evaluation of renal microcirculation in patients with chronic renal failure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental group | Experimental | Alprostadil and Beraprost sodium tablets are used to improve the microcirculation of CKD patients. |
|
| Anemia control group | No Intervention | Anemia patients | |
| Control group | No Intervention | Healthy person |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Alprostadil Injection | Drug | Participants are given alprostadil injection 10ug intravenously once a day for 2 weeks. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Nailfold microcirculation morphological integral | Nail fold capillary microscopy examination | Up to three and a half months |
| Nailfold microcirculation blood flow integral | Nail fold capillary microscopy examination | Up to three and a half months |
| Nail fold microcirculation perivascular loop integral | Nail fold capillary microscopy examination | Up to three and a half months |
| Measure | Description | Time Frame |
|---|---|---|
| The content of blood serum creatinine | Intravenous blood sampling | Up to three and a half months |
| The content of blood urea nitrogen | Intravenous blood sampling，uronoscopy |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dong Sun, MD | The Affiliated Hospital of Xuzhou Medical University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Affiliated Hospital of Xuzhou Medical University | Xuzhou | Jiangsu | 221000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 2314527 | Background | Leunissen KM, van den Berg BW, Cheriex EC, Slaaf DW, Reneman RS, van Hooff JP. Influence of fluid removal during haemodialysis on macro- and skin microcirculation. Haemodynamic pathophysiologic study of fluid removal during haemodialysis. Nephron. 1990;54(2):162-8. doi: 10.1159/000185838. | |
| 24955181 | Background |
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| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D000527 | Alprostadil |
| C048081 | beraprost |
| ID | Term |
|---|---|
| D011458 | Prostaglandins E |
| D011453 | Prostaglandins |
| D015777 | Eicosanoids |
| D005231 | Fatty Acids, Unsaturated |
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| Beraprost sodium tablets | Drug | Participants are given alprostadil injection 10ug intravenously once a day for 2 weeks ,then they take beraprost sodium tablets 40ug orally three times perday for 3 months. |
|
| Up to three and a half months |
| The content of blood cystatin C | Intravenous blood sampling | Up to three and a half months |
| eGFR | Intravenous blood sampling | Up to three and a half months |
| The content of blood albumin | Intravenous blood sampling | Up to three and a half months |
| The quantification of urinary protein | Uronoscopy | Up to three and a half months |
| The content of hemoglobin | Intravenous blood sampling | Up to three and a half months |
| Yuksel S, Pancar Yuksel E, Yenercag M, Soylu K, Zengin H, Gulel O, Meric M, Aydin F, Senturk N, Sahin M. Abnormal nail fold capillaroscopic findings in patients with coronary slow flow phenomenon. Int J Clin Exp Med. 2014 Apr 15;7(4):1052-8. eCollection 2014. |
| 24951141 | Background | Senet P, Fichel F, Baudot N, Gaitz JP, Tribout L, Frances C. [Nail-fold capillaroscopy in dermatology]. Ann Dermatol Venereol. 2014 Jun-Jul;141(6-7):429-37. doi: 10.1016/j.annder.2014.04.120. Epub 2014 Jun 2. French. |
| 3096534 | Background | Yuan SY. [Nail-fold microcirculatory flow in liver cirrhosis: diabetes mellitus and systemic lupus erythematosus]. Zhonghua Yi Xue Za Zhi. 1986 Aug;66(8):473-5, 512. No abstract available. Chinese. |
| 24607833 | Background | Paparde A, Neringa-Martinsone K, Plakane L, Aivars JI. Nail fold capillary diameter changes in acute systemic hypoxia. Microvasc Res. 2014 May;93:30-3. doi: 10.1016/j.mvr.2014.02.013. Epub 2014 Mar 6. |
| 8863336 | Background | Schumann L, Korten G, Holdt B, Holtz M. Microcirculation of the fingernail fold in CAPD patients: preliminary observations. Perit Dial Int. 1996 Jul-Aug;16(4):412-6. |
| 11279575 | Background | Hasegawa K, Pereira BP, Pho RW. The microvasculature of the nail bed, nail matrix, and nail fold of a normal human fingertip. J Hand Surg Am. 2001 Mar;26(2):283-90. doi: 10.1053/jhsu.2001.21519. |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D005227 |
| Fatty Acids |
| D008055 | Lipids |
| D005229 | Fatty Acids, Monounsaturated |
| D012898 | Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |