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The aim of this study is to compare the effects of high intensity interval exercise and moderate intensity continuous exercise on metabolic parameters, physical measures, fitness level, body composition and miRNA-143 level in patients with type 2 diabetes mellitus.
Volunteers with type 2 diabetes mellitus will be evaluated in terms of any contra-indication that will restrain them from making exercise. 90 male or female volunteers who are suitable in terms of inclusion/exclusion criteria will be invited for the study. Volunteers will be randomly distributed to one of the 3 groups. Each group will contain 30 participants. 1. group will make aerobic exercise which is in the form of high intensity interval exercise 2.group will make aerobic exercise which is in the form of moderate intensity continuous exercise 3. Control group. Exercise groups will be cycling under observation in the hospital setting. Control group will make simple stretching exercises at home. Participants will be requested to complete a 3 months of exercise. They will be evaluated before and at the end of the 3 months of exercise with physical measures such as waist and hip circumference, fitness level measured by exercise testing, body composition measured by bioimpedance, metabolic parameters such as blood glucose level, HbA1C and measured by blood tests.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High intensity interval exercise | Active Comparator | Participants with type 2 Diabetes mellitus in High intensity interval exercise (HIIE) group will make aerobic exercise using bicycle at high intensity followed by low intensity periods under observation in the hospital. |
|
| Moderate intensity continuous exercise | Active Comparator | Participants with type 2 Diabetes mellitus in Moderate intensity continuous exercise (MIC) group will make aerobic exercise using bicycle at moderate intensity during the session under observation in the hospital. |
|
| Control group | No Intervention | The participants in the control group will make stretching exercise at home |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| exercise | Other | Aerobic tyep of exercise will be made at different intensities in 2 groups. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in HbA1c level. | Change in HbA1c level measured in the blood after exercise compared to beginning | 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gulin Findikoglu, Assoc Prof | pamukkale university, Medical Faculty, PMR Department | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pamukkale University | Denizli | 20100 | Turkey (Türkiye) | |||
| Pamukkale University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36622777 | Derived | Findikoglu G, Altinkapak A, Yaylali GF. Is isoenergetic high-intensity interval exercise superior to moderate-intensity continuous exercise for cardiometabolic risk factors in individuals with type 2 diabetes mellitus? A single-blinded randomized controlled study. Eur J Sport Sci. 2023 Oct;23(10):2086-2097. doi: 10.1080/17461391.2023.2167238. Epub 2023 Feb 5. |
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| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D001519 | Behavior |
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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The study has 3 arms.
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Participants wil be making exercise. It is not possible to make participants blinded to the study.
| Denizli |
| 21600 |
| Turkey (Türkiye) |
| D009750 |
| Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |