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All neonates with congenital heart disease undergoing stage one palliation (Norwood procedure, Damus-Kaye-Stansel procedure) at Texas Children's Hospital will be regularly monitored for B-type natriuretic peptide (BNP) and Troponin level before the surgical procedure, on arrival to the cardiac intensive care unit after their surgical procedure, every 6 hours during the first 24 hours of the post-operative period, followed by daily levels for the first week, and then weekly during patient's regular laboratory work up schedule.
These cardiac biomarkers are linked to demographic, hemodynamic, respiratory, pharmacological data available via Sickbay.
All neonates with congenital heart disease undergoing stage one palliation (Norwood procedure, Damus-Kaye-Stansel procedure) at Texas Children's Hospital will be regularly monitored for B-type natriuretic peptide (BNP) and Troponin level before the surgical procedure, on arrival to the cardiac intensive care unit after their surgical procedure, every 6 hours during the first 24 hours of the post-operative period, followed by daily levels for the first week, and then weekly during patient's regular laboratory work up schedule.
These cardiac biomarkers are linked to demographic, hemodynamic, respiratory, pharmacological data available via Sickbay.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hypoplastic Left Heart Disease | Patients with congenital hypoplastic left heart disease who will undergo surgical palliation with Norwood procedure or DKS or Damus-Kaye-Stansel procedure |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Norwood Palliation / DKS / Damus-Kaye-Stansel procedure | Procedure | Norwood Palliation / DKS / Damus-Kaye-Stansel procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | Mortality up to anticipated Glenn Procedure | 3- 6 months depending on second stage procedure |
| Measure | Description | Time Frame |
|---|---|---|
| NEC | Incidence of Necrotizing enterocolitis | 3- 6 months depending on second stage procedure |
| Reintubation | Incidence of Reintubation |
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Inclusion Criteria:
Clinical diagnosis of Hypoplastic Left Heart Syndrome as congenital heart disease as a neonate
Exclusion Criteria:
Other diagnosis of congenital heart disease than Hypoplastic Left Heart Syndrome Patients older than 30 days
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Neonate with Hypoplastic Left Heart Syndrome
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| Name | Affiliation | Role |
|---|---|---|
| Marc M Anders, ND | Baylor College of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Texas Children's Hospital | Houston | Texas | 77030 | United States |
The data is blinded to other study investigators.
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| ID | Term |
|---|---|
| D018636 | Hypoplastic Left Heart Syndrome |
| D006330 | Heart Defects, Congenital |
| D006331 | Heart Diseases |
| ID | Term |
|---|---|
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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| 3- 6 months depending on second stage procedure |
| Cath intervention | Incidence of cath interventions | 3- 6 months depending on second stage procedure |