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The secretion of different kinds of antibiotic drugs in sweat is investigated. The concentration and pharmacodynamics of antibiotic drugs in sweat and blood will be compared.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| analysis of last resort antibiotic drug (Flucloxacillin, Imipenem, Vancomycin or Cefepim) in sweat and blood | Diagnostic Test | blood draw (4.7 ml EDTA) and sweat sample taken (Macroduct Sweat Collecting System) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in detection of last resort antibiotic Flucloxacillin in sweat. | detection of Flucloxacillin in sweat by mass spectrometry (proof of concept). | sample taken immediately before and 45 minutes after Flucloxacillin application |
| Change in detection of last resort antibiotic Imipenem in sweat. | detection of Imipenem in sweat by mass spectrometry (proof of concept). | sample taken immediately before and 60 minutes after Imipenem application |
| Change in detection of last resort antibiotic Vancomycin in sweat. | detection of Vancomycin in sweat by mass spectrometry (proof of concept). | sample taken immediately before and 5 hours after Vancomycin application |
| Change in detection of last resort antibiotic Cefepim in sweat. | detection of Cefepim in sweat by mass spectrometry (proof of concept). | sample taken immediately before Cefepim application and 2 hours, 4 hours, 6 hours, 8 hours after Cefepim application |
| Measure | Description | Time Frame |
|---|---|---|
| concentration (yg/ml) of last resort antibiotic Flucloxacillin in sweat. | quantification of Flucloxacillin in sweat by mass spectrometry. | sample taken immediately before and 45 minutes after Flucloxacillin application |
| concentration (yg/ml) of last resort antibiotic Imipenem in sweat. |
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Inclusion Criteria:
Exclusion Criteria:
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In- patients currently receiving intravenous antibiotic therapy (Cefepim, Flucloxacillin, Imipenem or Vancomycin) at University Hospital Basel/ Switzerland
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| Name | Affiliation | Role |
|---|---|---|
| Jens Eckstein, PD Dr. med | Chief Clinical Medical Office | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Basel | Basel | 4031 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32984371 | Derived | Brasier N, Widmer A, Osthoff M, Mutke M, De Ieso F, Brasier-Lutz P, Wolfe L, Aithal V, Broeckling CD, Prenni J, Eckstein J. Non-invasive Drug Monitoring of beta-Lactam Antibiotics Using Sweat Analysis-A Pilot Study. Front Med (Lausanne). 2020 Aug 25;7:476. doi: 10.3389/fmed.2020.00476. eCollection 2020. |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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quantification of Imipenem in sweat by mass spectrometry |
| sample taken immediately before and 60 minutes after Imipenem application |
| concentration (yg/ml) of last resort antibiotic Vancomycin in sweat. | quantification of Vancomycin in sweat by mass spectrometry | sample taken immediately before and 5 hours after Vancomycin application |
| concentration (yg/ml) of last resort antibiotic Cefepim in sweat. | quantification of Cefepim in sweat and blood by mass spectrometry | sample taken immediately before Cefepim application and 2 hours, 4 hours, 6 hours, 8 hours after Cefepim application |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |