This study will evaluate the safety and Pharmacokinetics (PK) of a single 3.36-mg dose of Collagenase Clostridium Histolyticum (CCH) in 4 quadrants concurrently, in subjects with Edematous fibrosclerotic panniculopathy (EFP).

This study will provide insight to the PK profile and safety of concurrent subcutaneous injections of CCH 0.84 mg/quadrant into 4 quadrants.

Inclusion Criteria:

• No subject will be dosed until all eligibility criteria have been satisfied. In order to be eligible to participate in the study, subjects must meet the following criteria:

  1. Be a female ≥18 years of age.
  2. Have evidence of cellulite within 4 quadrants (a quadrant is defined as a left buttock, right buttock, left posterolateral thigh or right posterolateral thigh) as assessed by the Investigator using the Clinician-Reported Photonumeric Cellulite Severity Scale (CR-PCSS) at the Screening visit; has a score of 2 (mild), 3 (moderate) or 4 (severe) as reported by the Investigator (CR-PCSS) in 4 quadrants at the Screening visit.
  3. Have a body mass index (BMI) between 20.0 and 35.0 kg/m^2, and intends to maintain stable body weight throughout the duration of the study (a variation of ≤10% from baseline body weight is permitted).
  4. Be willing to apply sunscreen to the dosing quadrants before each exposure to the sun while participating in the study (ie, screening through end of study).
  5. Be judged to be in good health, based upon the results of a medical history, physical examination, and laboratory profile at screening.
  6. Have a negative pregnancy test at the Screening visit and on Day -1 at admission (before injection of study drug); and be using an effective contraception method (e.g., abstinence, intrauterine device [IUD], hormonal [estrogen/progestin] contraceptives, or double barrier control) for at least 1 menstrual cycle prior to study enrollment and for the duration of the study; or be menopausal defined as 12 months of amenorrhea in the absence of other biological or physiological causes, as determined by the Investigator; or post-menopausal for at least 1 year; or be surgically sterile (i.e., hysterectomy, bilateral oophorectomy, tubal ligation).
  7. Be willing and able to cooperate with the requirements of the study.
  8. Voluntarily sign and date an informed consent form approved by the Institutional Review Board/Independent Ethics Committee/Human Research Ethics Committee (IRB/IEC/HREC).

Exclusion Criteria:

• A subject will be excluded from study participation if she:

  1. Has any of the following systemic conditions:

     1. Coagulation disorder
     2. Evidence or history of malignancy (other than excised basal-cell carcinoma) unless there has been no recurrence in at least 5 years
     3. History of keloidal scarring or abnormal wound healing
     4. Concurrent diseases or conditions that might interfere with the conduct of the study, confound the interpretation of the study results, or endanger the subject's well-being. Any questions about concurrent diseases should be discussed with the Medical Monitor.
     5. Evidence of clinically significant abnormalities on physical examination, vital signs, electrocardiogram (ECG), or clinical laboratory values.

  2. Has any of the following local conditions in the areas to be treated:

     1. History of lower extremity thrombosis or post-thrombosis syndrome
     2. Vascular disorder (e.g., varicose veins) in areas to be treated
     3. Inflammation or active infection
     4. Active cutaneous alteration including rash, eczema, psoriasis, or skin cancer
     5. Has a tattoo located within 2 cm of the site of injection

  3. Requires the following concomitant medications before or during participation in the trial:

     a. Anticoagulant or antiplatelet medication or has received anticoagulant or antiplatelet medication (except for ≤150 mg aspirin daily) within 7 days before injection of study drug

  4. Has a positive test on a urine drug screen for drugs of abuse

  5. Has a history of drug or alcohol abuse

  6. Has used any of the following for the treatment of EFP on the legs or buttock within the timelines identified below or intends to use any of the following at any time during the course of the study:

     1. Liposuction within the treatment quadrants during the 12-month period before injection of study drug
     2. Injections (e.g., mesotherapy); radiofrequency device treatments; laser treatment; or surgery (including subcision and/or powered subcision) within the treatment quadrants during the 12-month period before injection of study drug
     3. Endermologie or similar treatments within the treatment quadrants during the 6-month period before injection of study drug
     4. Massage therapy within the treatment quadrants during the 3-month period before injection of study drug
     5. Creams (e.g., Celluvera™, TriLastin®) to prevent or mitigate EFP within the treatment quadrants during the 2-week period before injection of study drug

  7. Is presently nursing a baby or providing breast milk for a baby

  8. Intends to become pregnant during the study

  9. Intends to initiate an intensive sport or exercise program during the study

  10. Intends to initiate a weight reduction program during the study

  11. Has received an investigational drug or treatment within 30 days before injection of study drug

  12. Has a known systemic allergy to collagenase or any other excipient of study drug

  13. Has received any collagenase treatments at any time prior to treatment

  14. Has been a subject in a previous cellulite clinical trial of CCH: AUX-CC-830, AUX-CC-831, EN3835-102, EN3835-104, EN3835-201, EN3835-202, EN3835-205, EN3835-302, EN3835-303, EN3835-304, and/or EN3835-209.

All (serious and nonserious) AEs, from Day 1 up to Day 22

All (serious and nonserious) AEs, whether elicited or observed during study visits or spontaneously reported by the participant, including events that occurred from the time the participant signed the study-specific consent form until completion of or discharge from the study.