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To evaluate the role of neurotrophic factors (NGF, GDNF, TRPV-1), to quantity tight junction proteins (ZO-1, occludin, claudin) and cytokines (IL-8, TNF-a, IL-1b) in the colonic mucosa of IBS patients and also clarify sex differences in the pathophysiology of IBS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| IBS group | Sham Comparator | Patients who were diagnosed with IBS according to the ROME III criteria. Colonoscopic mucosal biopsy was undertaken for every subject. |
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| Control group | Active Comparator | Healthy participants who have no gastrointestinal symptoms and no colonoscopic abnormality. Colonoscopic mucosal biopsy was undertaken for every subject. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| colonoscopic mucosal biopsy | Procedure | colonoscopic mucosal biopsy was undertaken for every participant |
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| Measure | Description | Time Frame |
|---|---|---|
| NGF, GDNF, and TRPV-1 mRNA expression of colonic mucosa | real-time qPCR | up to 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| ZO-1, Occludin, and Claudin mRNA expression of colonic mucosa | real-time qPCR and Western blot | up to 24 weeks |
| IL-8, TNF-a, and IL-1b mRNA expression of colonic mucosa | real-time qPCR |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nayoung Kim, Professor | Seoul National University Bundang Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do | 463-707 | South Korea |
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| ID | Term |
|---|---|
| D043183 | Irritable Bowel Syndrome |
| D003075 | Coitus |
| ID | Term |
|---|---|
| D003109 | Colonic Diseases, Functional |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
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| up to 24 weeks |
| D004066 | Digestive System Diseases |
| D012725 | Sexual Behavior |
| D001519 | Behavior |