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Observational study to determine if topical anesthetic and intraoperative oculocardiac reflex influence post strabismus surgery recovery.
In an observational study with de-identified data of oculocardiac reflex (OCR) and strabismus surgery under routine anesthesia, a cohort of ongoing patients received topical proparacaine immediately post op, or none. Co-variables were intraoperative opioid and OCR, patient age, type of surgery. Several post-operative recovery outcome variables were prospectively monitored.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| proparacaine | Received topical proparacaine 0.5% with routine antibiotic-steroid ointment in operative eye(s) following strabismus surgery |
| |
| No proparacaine | Received no topical proparacaine 0.5% but did receive routine antibiotic-steroid ointment in the operative eye(s) following strabismus surgery |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Topical Solution | Drug | proparacaine 0.5% eye drop |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| pain (post op pain Likert scale) | pain scale description / observation.. Pain is ranked by patient or nurse from 0 (no pain) to 9 (much pain) | hours (1-4) in recovery room |
| Measure | Description | Time Frame |
|---|---|---|
| nausea | observed or described nausea (presence or absence of nausea / vomiting) | hours (1-4) in recovery room |
| heart rate | recovery room heart rate |
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Inclusion Criteria:
Exclusion Criteria:
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strabismus surgery patients
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| Name | Affiliation | Role |
|---|---|---|
| Robert W Arnold, MD | Alaska Blind Child Discovery | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31819352 | Background | Arnold RW, Bond AN. Does Topical Proparacaine Improve Postoperative Comfort After Strabismus Surgery? Clin Ophthalmol. 2019 Nov 20;13:2279-2283. doi: 10.2147/OPTH.S230498. eCollection 2019. | |
| 29733898 | Result | Arnold RW, Biggs RE, Beerle BJ. Intravenous dexmedetomidine augments the oculocardiac reflex. J AAPOS. 2018 Jun;22(3):211-213.e1. doi: 10.1016/j.jaapos.2018.01.016. Epub 2018 May 5. |
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| ID | Type | URL | Comment |
|---|---|---|---|
| Individual Participant Data Set | View IPD |
Study Website access
current- ongoing
public
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| ID | Term |
|---|---|
| D013285 | Strabismus |
| D001919 | Bradycardia |
| D009325 | Nausea |
| D010146 | Pain |
| ID | Term |
|---|---|
| D015835 | Ocular Motility Disorders |
| D003389 | Cranial Nerve Diseases |
| D009422 | Nervous System Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D012996 | Solutions |
| C005717 | proxymetacaine |
| ID | Term |
|---|---|
| D004364 | Pharmaceutical Preparations |
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| hours (1-4) while in recovery room |
| time to recovery | time in recovery room | minutes (30-240) from entry recovery room to discharge |
deidentified OCR topical anesthetic recovery outcomes |
| D001145 |
| Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D009461 | Neurologic Manifestations |