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Clubfoot is one of the most common birth defects, with a prevalence in Europe estimated between 1 and 4.5 for 1000 live birth.
It is useful to distinguish the forms of isolated clubfoot, and the forms related to others morphological abnormalities (complex clubfoot). For the complex forms, the clubfoot can be integrated in a syndromic association, be the consequence of a serious harm of the central nervous system, be associate to a genetic musculo-skeletal disease or wether be associated to a karyotype abnormality.
In those cases, the prognosis depends more about the associated morphological abnormalities that can be the beginning of a severe disability or incompatible with life or any anomaly of the karyotype that clubfoot itself.
In case of several morphological abnormalities, to propose invasive samples with realization of a karyotype and chromosome analysis with CGH array is a consensual attitude.
What the investigators should recommended to the parents in case of isolated form is less obvious and the question of antenatal investigations can not be answered clearly in the literature. Thus, the management of these patients may vary from one CPDP to another.
This study project will make it possible to analyze the management offered to patients whose fetuses have club feet and to study the results of the various examinations carried out in order to adapt the prenatal counselling and to define the best diagnostic strategy to propose to the future parents.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Infants who are treated for clubfoot | Infants who are treated for clubfoot in the reference reeducation center |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Invasive analysis (caryotype, CGH array) | Other | Invasive analysis (caryotype, CGH array) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Antenatal detection rate of clubfeet | Antenatal detection rate of clubfeet in percentage | At birth |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of isolated clubfoot among children followed for clubfoot | Rate of isolated clubfoot among children followed for clubfoot in percentage | At birth |
| Rate of refered for second-degree examination |
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Inclusion criteria:
Exclusion criteria:
- Non confirmed clubfoot after birth
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Infants with a clubfoot, antenatal diagned or not, treated at the " Institut Saint Pierre, Plavas-les-flots, France "
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| Name | Affiliation | Role |
|---|---|---|
| Florent FUCHS, PhD | University Hospital, Montpellier | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Uhmontpellier | Montpellier | 34295 | France |
NC
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| ID | Term |
|---|---|
| D003025 | Clubfoot |
| ID | Term |
|---|---|
| D000070558 | Talipes |
| D005531 | Foot Deformities, Acquired |
| D005530 | Foot Deformities |
| D009140 | Musculoskeletal Diseases |
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| Prenatal management | Other | Prenatal management |
|
Rate of refered for second-degree examination in percentage
| At birth |
| Rate of invasive samples taken and their results | Rate of invasive samples taken and their results in percentage | At birth |
| Rate of files submitted to our reference center committee | Rate of files submitted to our reference center committee in percentage | At birth |
| Research rates of musculoskeletal genetic disease | Research rates of musculoskeletal genetic disease in percentage | At birth |
| Rate of consultation with geneticist | Rate of consultation with geneticist in percentage | At birth |
| Rate of consultation with a orthopedic surgeon | Rate of consultation with a orthopedic surgeon in percentage | At birth |
| D005532 |
| Foot Deformities, Congenital |
| D038061 | Lower Extremity Deformities, Congenital |
| D017880 | Limb Deformities, Congenital |
| D009139 | Musculoskeletal Abnormalities |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |