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| ID | Type | Description | Link |
|---|---|---|---|
| 2017-A03022-51 | Other Identifier | N° ID-RCB |
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a project that did not get off the ground because the authorisation had expired
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Autografting of fat cells is widely used in plastic surgery in breast reconstruction, burn scars, unsightly scars etc. It is known that the autografting of fat cells not only makes it possible to bring adipocytes, and thus to create a volume, but also promotes neo-angiogenesis by providing the growth factors which allows an improvement of the local cutaneous tissue.
Currently the investigators perform this action in their service on healed eschars, by analogy with burn scars that are also dystrophic, so as to improve cutaneous trophicity, and reduce the recurrence of eschars on these scars. However, the literature on the autografting of fat cells on eschars is limited.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Autograft fat | Experimental | Paraplegic patients with healed pelvic eschar |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Autograft fat | Procedure | autograft fat |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rate of recurrence of eschar | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Time of occurrence of recurrence of eschar (censored criterion) | 12 months | |
| POSAS scale score | Clinical evaluation | 12 months |
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Inclusion Criteria:
Patient between 18 and 65 years old;
presenting a medullary, post-traumatic or congenital lesion, with consequent paraplegic sequelae;
With a history of eschar:
Affiliated to a social security ;
Written informed consent.
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sylvie AILLET | Rennes University Hospital | Principal Investigator |
| Cécile MEAL | Rennes University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Rennes | Rennes | France |
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| Vancouver score |
Clinical evaluation |
| 12 months |
| Improvement Vancouver score | Clinical evaluation | 12 months |
| Number of recurrence of eschar | Clinical evaluation : non-recurrence | 12 months |
| Evaluation of neovascularization | by Speckle laser doppler | 12 months |
| Volumetric assessment | by contouring MRI | 12 months |
| Analysis of pro-angiogenic genes expressed in the stromal vascular fraction of the injected fat | RNA PCR | 12 months |
| Analysis of the stromal vascular fraction of the injected fat | 12 months |