Influence of the Initial Level of Consciousness on Early, Goal-directed Mobilization

Influence of the Initial Level of Consciousness on Early, Goal-directed Mobilization

Analysis of the randomized controlled SOMS trial of early, goal-directed mobilization to investigate if the treatment effect is consistent and independent of the initial conscious state without evidence of moderation or modification.

Inclusion Criteria:

• aged 18 years or older
• mechanically ventilated for less than 48 h and expected to require mechanical ventilation for at least another 24 h at the time of screening
• functionally independent at baseline with a Barthel Index Score of at least 70 at 2 weeks before admission to the ICU based on patient or proxy completion of the measure

Exclusion Criteria:

• admitted to hospital for more than 5 days before screening
• a motor component of Glasgow Coma Scale (GCS) lower than 5
• irreversible disorder with a 6-month mortality of greater than 50%,
• raised intracranial pressure
• cardiopulmonary arrest
• unstable fractures contributing to probable immobility
• inclusion in another trial at the same time
• acute myocardial infarction
• do not have lower part of their legs
• have a rapidly developing neuromuscluar disease
• pregnant
• ruptured or leaking aortic aneurysm