patients 6-25 years old upon diagnostic evaluation will be recruited . study population will comprise of two groups: newly diagnosed IBD patients/ Celiac disease and healthy controls.

upon enrollment, subjects will fill out sleeping habits questioners, demographic data, medical history.

blood samples will be drawn for CRP and clock gene expression in systemic WBC. intestinal biopsies will be snap frozen for clock gene extraction and amplification only for patients with IBD.

Inclusion Criteria:

• IBD or celiac patients with a confirmed diagnosis, recruited upon diagnosis.
• Both male and female
• Age 6-25 years
• Medically treated for IBD in our institute.

Exclusion Criteria:

• Genetic disorder.
• Known primary or secondary immunodeficiency .
• Pregnancy or lactating

patients medically treated in our institute.