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| ID | Type | Description | Link |
|---|---|---|---|
| 1R15NS098340-01A1 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Neurological Disorders and Stroke (NINDS) | NIH |
| University of Idaho | OTHER |
| Mayo Clinic | OTHER |
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People with Parkinson disease commonly experience difficulty driving, which requires the arms and legs to do different tasks simultaneously. Driving difficulties can lead to isolation, depression, loss of independence and mobility, and increased incidence of car accidents. Through understanding the impact of Parkinson disease on mechanisms underlying attention and multi-limb control, training and rehabilitation programs can better focus on the needs of drivers with Parkinson disease. The proposed study aims to address this need by taking measures of simulated driving at one point in time. Subjects with PD are tested at a single time point when they are at their "best" point in their day and on another day when they are at their worst and are about to take their next dose of medication. Healthy age-matched subjects are not taking anti-parkinson medication so are tested at only one point.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Parkinson Disease | Observation of individuals with idiopathic Parkinson disease performing a multilimb dual task using the arm and the leg. |
| |
| Control | Observation of healthy age-matched individuals will perform a multilimb dual task using the arm and the leg. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| multilimb dual task | Other | control of arm and foot in two attentional contexts of simulated driving |
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| Measure | Description | Time Frame |
|---|---|---|
| Dual Task Effect on Arm and Foot Tasks | The Dual Task Effect is the performance measure of the arm and foot task, respectively, in the dual task relative to the single task, expressed as a percentage. | Subjects with PD: Two 90-minute sessions within a week; Healthy controls: One 90-minute session, observation of simulated driving. |
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Inclusion Criteria:
Exclusion Criteria:
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Individuals will be recruited through collaboration with hospitals, clinics, physical therapy centers, private practice physicians and physical therapists, neurology-based fitness centers, community centers, PD support groups, online trial-matching services (e.g., FoxTrialFinder.michaeljfox.org), word of mouth, and advertising. Recruitment will be limited to the greater Phoenix metropolitan area.
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| Name | Affiliation | Role |
|---|---|---|
| Tara L McIsaac, PhD, PT | A.T. Still University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| A.T. Still University Arizona School of Health Sciences | Mesa | Arizona | 85206 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26080755 | Background | McIsaac TL, Benjapalakorn B. Allocation of attention and dual-task effects on upper and lower limb task performance in healthy young adults. Exp Brain Res. 2015 Sep;233(9):2607-17. doi: 10.1007/s00221-015-4333-6. Epub 2015 Jun 17. | |
| 25961027 | Background | McIsaac TL, Lamberg EM, Muratori LM. Building a framework for a dual task taxonomy. Biomed Res Int. 2015;2015:591475. doi: 10.1155/2015/591475. Epub 2015 Apr 19. |
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It is not yet known if there will be a plan to make IPD available. Institutional infrastructure being developed.
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| 30076275 | Background | Thompson T, Poulter D, Miles C, Solmi M, Veronese N, Carvalho AF, Stubbs B, Uc EY. Driving impairment and crash risk in Parkinson disease: A systematic review and meta-analysis. Neurology. 2018 Sep 4;91(10):e906-e916. doi: 10.1212/WNL.0000000000006132. Epub 2018 Aug 3. |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |