PET/MR in Locally Advanced Nasopharyngeal Carcinoma

Inclusion Criteria:

• Patients with newly histologically confirmed non-keratinizing carcinoma.
• Tumor staged T1-4N0-3M0 （according to the 8th AJCC staging system）
• Performance status: KPS>70
• With normal liver function test (ALT, AST <1.5ULN)
• Renal: creatinine clearance >60ml/min
• Without hematopathy,marrow: WBC >4*109/L, HGB>80G/L, and PLT>100*109/L.
• Written informed consent

Exclusion Criteria:

• Adenocarcinoma
• Age >70
• Prior malignancy (except adequately treated carcinoma in-situ of the cervix or · basal/squamous cell carcinoma of the skin)
• Previous chemotherapy or radiotherapy (except non-melanomatous skin cancers outside the intended RT treatment volume)
• Patient is pregnant or lactating
• Any severe intercurrent disease, which may bring unacceptable risk or affect the compliance of the trial, for example, unstable cardiac disease requiring treatment, renal disease, chronic hepatitis, diabetes with poor control (fasting plasma glucose >1.5×ULN), or emotional disturbance.