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The research plan is divided into two parts. The first part is the correlation study .It is planned to include women who prepare for pregnancy or in the early stages of pregnancy to carry out the detection of 25 loci SNP of 21 genes of 9 nutrients, to predict the nutritional abnormalities of 9 nutrients, and to determine the nutritional status of 9 nutrients, and then verify the correlation between nutrient metabolism related gene SNP and nutrient nutrition status .The second part selects iron and selenium which are commonly lacking in Chinese women of childbearing age. A intervention study is designed for these two nutrients. According to the SNP grouping of related gene loci, observe the effect of nutrition intervention and explore the nutrition intervention strategies of different SNP individuals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal iron | Experimental |
| |
| Weak iron | Experimental |
| |
| Normal selenium | Experimental |
| |
| Weak selenium | Experimental |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Normal iron | Dietary Supplement | The intervention was divided into two stages, the first stage lasted for 4 weeks, and the dosage used was the dietary nutrient recommendation amount, namely the dietary recommendation amount standard for early pregnancy (iron 20mg/d), and the middle stage of pregnancy (iron 24mg/d). The second stage lasts for 4 weeks. For subjects in iron deficiency, the maximum tolerable amount (iron 42mg/d) is used for intervention. For those with good nutritional status, the dietary recommendation amount is maintained. |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between the results of nutritional evaluation of selenium-related genes and selenium levels in vivo | The correlation between the nutrition evaluation results of selenium gene monitoring and the levels of selenium in vivo | lasted for 4 weeks |
| Correlation between the results of nutritional evaluation of iron-related genes and iron levels in vivo | The correlation between the nutrition evaluation results of iron gene monitoring and the levels of iron in vivo | lasted for 4 weeks |
| Correlation between the results of nutritional evaluation of vitamin B6-related genes and vitamin B6 levels in vivo | The correlation between the nutrition evaluation results of vitamin B6 gene monitoring and the levels of vitamin B6 in vivo | lasted for 4 weeks |
| Correlation between the results of nutritional evaluation of vitamin B12-related genes and vitamin B12 levels in vivo | The correlation between the nutrition evaluation results of vitamin B12 gene monitoring and the levels of vitamin B12 in vivo | lasted for 4 weeks |
| Correlation between the results of nutritional evaluation of vitamin D-related genes and vitamin D levels in vivo | The correlation between the nutrition evaluation results of vitamin D gene monitoring and the levels of vitamin D in vivo | lasted for 4 weeks |
| Correlation between the results of nutritional evaluation of pantothenic acid-related genes and pantothenic acid levels in vivo | The correlation between the nutrition evaluation results of pantothenic acid gene monitoring and the levels of pantothenic acid in vivo |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yanpin Liu, bachelor | Contact | +861069159088 | liuyp1227@vip.sina.com | |
| Yixuan Hou, master | Contact | +8618810112590 | 15612494030@163.com |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34455263 | Derived | Zhao R, An Z, Sun Y, Xia L, Qiu L, Yao A, Liu Y, Liu L. Metabolic profiling in early pregnancy and associated factors of folate supplementation: A cross-sectional study. Clin Nutr. 2021 Sep;40(9):5053-5061. doi: 10.1016/j.clnu.2021.01.012. Epub 2021 Jan 23. |
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|
| Weak iron | Dietary Supplement | The intervention was divided into two stages, the first stage lasted for 4 weeks, and the dosage used was the dietary nutrient recommendation amount, namely the dietary recommendation amount standard for early pregnancy (iron 20mg/d), and the middle stage of pregnancy (iron 24mg/d). The second stage lasts for 4 weeks. For subjects in iron deficiency, the maximum tolerable amount (iron 42mg/d) is used for intervention. For those with good nutritional status, the dietary recommendation amount is maintained. |
|
| Normal selenium | Dietary Supplement | The intervention was divided into two stages, the first stage lasted for 4 weeks, and the dosage used was the dietary nutrient recommendation amount, namely the dietary recommendation amount standard for early pregnancy (selenium 60ug/d), and the middle stage of pregnancy (selenium 65ug/d). The second stage lasts for 4 weeks. For subjects in selenium deficiency, the maximum tolerable amount (selenium 400ug/d) is used for intervention. For those with good nutritional status, the dietary recommendation amount is maintained. |
|
| Weak selenium | Dietary Supplement | The intervention was divided into two stages, the first stage lasted for 4 weeks, and the dosage used was the dietary nutrient recommendation amount, namely the dietary recommendation amount standard for early pregnancy (selenium 60ug/d), and the middle stage of pregnancy (selenium 65ug/d). The second stage lasts for 4 weeks. For subjects in selenium deficiency, the maximum tolerable amount (selenium 400ug/d) is used for intervention. For those with good nutritional status, the dietary recommendation amount is maintained. |
|
| lasted for 4 weeks |
| Correlation between gestational diabetes-related gene monitoring results and glycosylated hemoglobin，fasting blood glucose, fasting insulin levels in vivo | The correlation between the nutrition evaluation results of gestational diabetes-related gene monitoring and the levels of glycosylated hemoglobin，fasting blood glucose, fasting insulin in vivo | lasted for 4 weeks |
| Correlation between gestational hypertension-related gene monitoring results and homocysteine, serum folic acid and RBC Folate levels in vivo | TThe correlation between the nutrition evaluation results of gestational hypertension-related gene monitoring and the levels of homocysteine, serum folic acid and RBC Folate in vivo | lasted for 4 weeks |
| Correlation between hyperlipidemia-related gene monitoring results and the level of plasma lipid in vivo. | The correlation between the nutrition evaluation results of hyperlipidemia-related gene monitoring and the levels of plasma lipid in vivo | lasted for 4 weeks |
| nutritional status | The nutritional status of selenium was compared between the normal selenium and week selenium group; The nutritional status of iron was compared between the normal iron and the weak group. Meanwhile, compare the selenium and iron nutritional status of the four groups before and after the intervention. | lasted for 4 weeks |