Efficacy and Safety of Low Dose Thalidomide in Transfusion Dependent Thalassemia

Efficacy and Safety of Low Dose Thalidomide in Transfusion Dependent Thalassemia Patients of Pakistan

Thalidomide is known to have hypnosedative, immuno-modulatory and anti-angiogenic effects. The drug is widely used in several neoplastic disorders (e.g. multiple myeloma and malignant melanoma), inflammatory conditions (e.g. Crohn's disease) and skin disorders (e.g. leprosy). Thalidomide has been successfully used in adult thalassemia patients. The current study explores its role in transfusion-dependent thalassemia patients.

Inclusion Criteria:

• Transfusion dependent thalassemia patients refractory to Hydroxyurea

Exclusion Criteria:

• Those with active systemic comorbidity, with past personal or family history of thrombophilia, recent fracture or recent major surgery