Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Fetal medicine in China is still a new, young discipline, and the development is very rapid. After nearly 10 years of development, the clinical diagnosis and treatment guidelines of some complicated twin diseases has been established , but they are still needed to be improved. Through this study, the investigators expect to achieve better prediction indicators and early intrauterine precise diagnosis of complicated twin diseases. Also, better procedures of implementing effective intrauterine intervention and assessing the safety and effectiveness of intrauterine intervention are anticipated to be established.
A better guideline for complicated twin diseases are anticipated to be established in China. Molecular genetics and imaging technology are applied to evaluate the outcome and prognosis of intrauterine intervention for complex twin diseases. 3D printing technology is used to assist the preoperative evaluation of fetal intrauterine intervention. Better fetal intrauterine intervention technique and prognosis evaluation are expected to be established.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TOCTD | Experimental | Pregnancy women with complicated twin diseases, who are able to withstand risks of intrauterine treatments and informed consent, will be involved. Fetoscope technique will be administered in suitable patients. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fetoscope technique | Procedure | Intrauterine intervention with fetoscope technique will be applied to treat complex twin diseases with intention to improve the prognosis of patients. |
| Measure | Description | Time Frame |
|---|---|---|
| Gene expression of fetuses | DNA methylation, histone acetylation etc. assessed by analyses of fetal blood and amniotic fluid. | At 20 week of gestational age |
| Change of volume of amniotic fluid in Milliliter | Measured by doctors of sonography | At every two week from the sixteenth week of gestational age to delivery of babies |
| Change of umbilical artery blood flow | Measured by doctors of sonography | At every two week from the sixteenth week of gestational age to delivery of babies |
| Measure | Description | Time Frame |
|---|---|---|
| Neurodevelopment at early childhood | Including adaptive, gross motor, fine motor, language, and social function; assessed using Gesell Developmental Schedules. | At age of 1 year old |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Caixia Liu | Contact | 86-18902451716 | liucx1716@163.com | |
| Shaojiang Liu | Contact | 86-18002454803 | liushaojiang1995@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| Caixia Liu | Shengjing Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shengjing Hospital | Recruiting | Shenyang | Liaoning | China |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D004200 | Diseases in Twins |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
Pregnancy women with complicated twin diseases, who are able to withstand risks of intrauterine treatments and informed consent.
Not provided
Not provided
Not provided
Not provided