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The purpose of this study is to understand the reliability of [18F]-FTC-146 brain uptake in healthy controls.
The purpose of this study is to understand the reliability of [18F]-FTC-146 brain uptake in healthy controls under test and retest conditions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| [18F]-FTC-146 | Experimental | [18F]-FTC-146 |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| [18F]-FTC-146 | Drug | Two 5 mCi [18F]-FTC-146 doses will be administered intravenously on two separate scan days at least one week apart (total per study = 10 mCi) Participants who complete both test days will receive 10 mCi total dose; however, if a participant is unable to return for a second test day due to unforeseen circumstances, they will receive 5 mCi total dose. |
| Measure | Description | Time Frame |
|---|---|---|
| Reliability under test retest conditions | Regional brain uptake of [18F]FTC-146 will be analyzed by kinetic modeling with metabolite-corrected arterial input functions to establish stability and reproducibility of [18F] FTC-146 VT in humans (n=6) under test and retest conditions. | 1 week |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Carolyn Rodriguez, MD, PhD | Stanford University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Psychiatry and Behavioral Sciences | Stanford | California | 94304 | United States |
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| Label | URL |
|---|---|
| Rodriguez Lab Website | View source |
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| ID | Term |
|---|---|
| C577112 | 6-(3-fluoropropyl)-3-(2-(azepan-1-yl)ethyl)benzo(d)thiazol-2(3H)-one |
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