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| Name | Class |
|---|---|
| National Malaria Control Program, Myanmar | OTHER_GOV |
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A cross-sectional study will be conducted in selected 2 sentinel sites for assessment of drug resistance falciparum and vivax among asymptomatic infection in migrant workers in Myanmar.
Although malaria prevalence is decreasing in Myanmar, drug resistance threatens the malaria elimination by 2030 especially high risk persons including migrant population. Previous study indicated that asymptomatic malaria parasite carried drug resistance gene such as K13 mutant that is genetically responsible for artemisinin resistant falciparum malaria. These asymptomatic carries may be a source to spread the disease and it is very important to conduct the surveillance on drug resistance status among high vulnerable persons. Unfortunately, there is no study to assess the drug resistance molecular markers in asymptomatic malaria among migrant workers in Myanmar. Therefore, this study fulfills the gaps of knowledge on important of asymptomatic hidden infection exploring to formulate the recommendation for elimination of malaria in Myanmar.
In this study, asymptomatic infections are screened by rapid diagnostic test, microscopy and molecular methods.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Shwegyin | Shwehyin is a Township in Bago Region. We will use the comparison between the two sentinel sites by the name of Shwegyin and Pinlebu. We will compare the prevalence of asymptomatic infection between these two sites. Then proportion of the drug resistance molecular markers will be compared. |
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| Pinlebu | Pinlebu is a township in Sagaing Region. We will use the comparison between the two sentinel sites by the name of Shwegyin and Pinlebu. We will compare the prevalence of asymptomatic infection between these two sites. Then proportion of the drug resistance molecular markers will be compared. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Drug resistance molecular markers | Genetic | Proportion of the drug resistance molecular markers will be found-out and compared. |
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| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of the asymptomatic infection among the study population | Number of the hidden malaria cases by RDT, microscopy or nested PCR (molecular method) | 1 week |
| Proportion of the drug resistance molecular markers among asymptomatic infections | Among the asymptomatic cases, molecular markers will be analyzed (K13 and pfmdr1 copy number for falciparum and pvcrt-o, pvmdr1, pvdhps and pvdhfr gene analysis for vivax cases by Sanger Sequencing. | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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The activity will cover the migrant population of the Shwegyin Township (Bago Region) and Pinlebu Township (Sagaing Region).
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| Name | Affiliation | Role |
|---|---|---|
| Myat H Nyunt, PhD | Department of Medical Research | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dr. Myat Phone Kyaw | Yangon | 11191 | Burma |
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| ID | Term |
|---|---|
| D058345 | Asymptomatic Infections |
| D008288 | Malaria |
| ID | Term |
|---|---|
| D007239 | Infections |
| D058070 | Asymptomatic Diseases |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
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The DNA samples will be kept at -80 degree C according to the consent of the participants. The samples will be kept with code number and limited restricted for use in future research.
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D011528 | Protozoan Infections |
| D010272 | Parasitic Diseases |
| D000096724 | Mosquito-Borne Diseases |
| D000079426 | Vector Borne Diseases |