Postoperative Analgesic Effect of Hydromorphone on Partial Pulmonary Resection Under Video-assisted Thoracoscopy

Postoperative Analgesic Effect of Hydromorphone on Chinese Patients Receiving Partial Pulmonary Resection Under Video-assisted Thoracoscopy

Postoperative pain remains relatively high within 48h for Chinese patients who receive video-assisted thoracoscopic surgery. Multimodal analgesia combines several agents and/or techniques to function on diverse nociceptive mechanisms to enhance pain relief and lessen side effect. Hydromorphone is a hydrogenated ketone of morphine and approximately 5-10 times more potent. There lacks about efficacy and efficiency of hydromorphone in electrical pump for patient controlled intravenous analgesic (PCIA).

Inclusion Criteria:

• 70≥ Age ≥18
• Selective operation lung section with video-assisted thoracic surgery (VATS)
• III ≥ American Society of Anesthesiologists classification (ASA classification) ≥I
• Patients informed and agreed to join the study

Exclusion Criteria:

• Abnormal function of liver and kidney
• Allergic- dependence history of alcohol, opioids and Local anesthetics
• No noncompliance
• Mental disease history，language communication disorder，cicatricial diathesis
• Underweight or overweight（BMI<18 or >30)
• Patients not suitable for clinical subjects for other reasons
• Sedatives, analgesics, antiemetic drugs and anti pruritus drugs were used within 24 hours before the operation.
• History of previous abnormal anaesthesia
• Women during pregnancy or lactation