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The study is a Comparative Clinical and Biochemical Study Evaluating the effect of Proton Pump I nhibitors versus histamine 2 Receptor antagonists as an adjuvant with chemotherapy in patients with Non-hodgkin Lymphoma.
The study is a Comparative Clinical and Biochemical Study Evaluating the effect of Proton Pump Inhibitors versus histamine 2 Receptor antagonists as an adjuvant with chemotherapy in patients with Non-hodgkin Lymphoma to compare the difference in efficacy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CHOP | Active Comparator | CHOP only |
|
| CHOP Plus Lanzoprazole | Active Comparator | CHOP Plus Lanzoprazole 60 mg |
|
| CHOP Plus Famotidine | Active Comparator | CHOP Plus Famotidine 40 mg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CHOP | Drug | CHOP only |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients eith radiological and clinical improvement | Number of patients eith radiological and clinical improvement after cycles of chemotherapy | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sherief Abd-Elsalam, MD | Contact | 00201147773440 | sheriefabdelsalam@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Sahar K Hegazy, Prof | Clinical pharmacy Department- Tanta University | Principal Investigator |
| Sahar M El-Haggar, prof | Clinical pharmacy Department- Tanta University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sherief Abd-Elsalam | Recruiting | Cairo | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33394214 | Derived | Hegazy SK, El-Haggar SM, Alhassanin SA, El-Berri EI. Comparative randomized trial evaluating the effect of proton pump inhibitor versus histamine 2 receptor antagonist as an adjuvant therapy in diffuse large B-cell lymphoma. Med Oncol. 2021 Jan 4;38(1):4. doi: 10.1007/s12032-020-01452-z. |
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| ID | Term |
|---|---|
| D008223 | Lymphoma |
| ID | Term |
|---|---|
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
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| ID | Term |
|---|---|
| C034587 | CHOP protocol |
| D015738 | Famotidine |
| ID | Term |
|---|---|
| D013844 | Thiazoles |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D001393 | Azoles |
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| CHOP Plus Lanzoprazole |
| Drug |
CHOP plus Lanzoprazole 60 mg |
|
|
| CHOP Plus Famotidine | Drug | CHOP Plus Famotidine 40 mg |
|
|
| Suzan A Alhassanin, Ph D |
| Clinical Oncology Department-Menoufia University |
| Study Director |
| Eman I A El berri, Msc | Clinical pharmacy Department-Tanta University | Principal Investigator |
| D006425 | Hemic and Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
| D006573 |
| Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |