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This study intends to evaluate the impact of resistance training variable manipulation (intensity and volume) on body composition, fatigability and functional capacity in postmenopausal breast cancer survivors.
The treatment for breast cancer (chemotherapy, radiotherapy and hormone therapy) provokes collateral effects,such as muscle mass and strength losses, increase of fat mass, fatigue and disability and reduced quality of life in postmenopausal breast cancer survivors. The resistance training is assumed as a non-pharmacologic interventions in postmenopausal breast cancer survivors. However, it is unclear whether the manipulation of training variables (intensity and volume) maximize the effects of resistance training on body composition, fatigability and functional capacity in postmenopausal breast cancer survivors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group, CT | Other | In the CT, the postmenopausal breast cancer survivers does not perform exercise. |
|
| Lower-load resistance training (LL) | Experimental | In the LL, the postmenopausal breast cancer survivers will be submitted to 12 weeks of resistance training with low loads ( i.e. three sets with 30% of one-repetition maximum). |
|
| Higher-load resistance training (HL) | Experimental | In the HL, the postmenopausal breast cancer survivers will be submitted to 12 weeks of resistance training with high loads (i.e. three sets with 80% of one maximum repetition). |
|
| Higher-volume resistance training (HV) | Experimental | In the HV, the postmenopause breast cancer survivers will be submitted to 12 weeks of resistance training with high volume ( i.e. six sets with 80% one maximum repetition). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control group | Other | The volunteers will not performed the interventions. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation the Fatigability | The fatigability will be evaluate by 60 maximum voluntary isometric contractions (3 s contraction, 2 s rest) in knee extensors at 70 degree | pre and post intervention (i.e. 12 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| Four- meter walk test | The volunteers will walk 4 meter. The time will be computed to determine the gait velocity (m/s). | pre and post intervention (i.e. 12 weeks) |
| Fat mass | The fat mass (kg) will be assessed via dual-energy x-ray absorptiometry scanning (iDXA; GE Healthcare-Luna, Madison, WI; software Encore version 14.10). |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of force development (RFD) | RFD will be measured by a rapid maximum isometric voluntary contraction of the one-sidedly knee extension force pulses of right leg. | pre and post intervention (i.e. 12 weeks) |
| Electromyography |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fábio L Orsatti, PhD | Contact | +55343700-6634 | fabiorsatti@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Fábio L Orsatti, PhD | Federal University of Triângulo Mineiro | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Post-degree program in physical education | Recruiting | Uberaba | MG - Minas Gerais | 38061-500 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19627658 | Background | Holmes J, Powell-Griner E, Lethbridge-Cejku M, Heyman K. Aging differently: Physical limitations among adults aged 50 years and over: United States, 2001-2007. NCHS Data Brief. 2009 Jul;(20):1-8. No abstract available. | |
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| Lower-load resistance training (LL) |
| Other |
The volunteers will be perform the resistance training, three times a week for 12 weeks on non-consecutive days, three sets with 30% of 1RM and repetition until or close to failure in each set and 1.5-min of rest between sets and exercises. |
|
| Higher-load resistance training (HL) | Other | The volunteers will be perform the resistance training, three times a week for 12 weeks on non-consecutive days, three sets with 80% of 1RM and repetition until or close to failure in each set and 1.5-min of rest between sets and exercises. |
|
| Higher-volume resistance training (HV) | Other | The volunteers will be perform the resistance training, three times a week for 12 weeks on non-consecutive days, six sets with 80% of 1RM and repetition until or close to failure in each set and 1.5-min of rest between sets and exercises. |
|
| pre intervention and post intervention (i.e. 12 weeks) |
| Muscle strength | Muscle strength will be evaluated by one repetition maximum (1RM) test. | pre and post intervention (i.e. 12 weeks) |
| Six Minutes-walk test (6MWT) | The volunteers will walk 6 minutes. The distance (meters) will be recorded after completes the test. The 6MWT will be performed indoor, on a flat floor in a sports court. | pre and post intervention (i.e. 12 weeks) |
| Timed Up and Go test | The volunteers will be advised to get up from a chair, walk three meters, turn around, go back to the chair, and sit down. The time (seconds) will be recorded. The test will be performed indoor, on a flat floor in a sports court. | pre and post intervention (i.e. 12 weeks) |
| Five-times-sit-to-stand test | The volunteers will rise from a chair and returned to the seated position as quickly as possible for five repetitions. The time will be recorded (seconds). | pre and post intervention (i.e. 12 weeks) |
| Muscle mass | The muscle mass (kg) will be assessed via dual-energy x-ray absorptiometry scanning (iDXA; GE Healthcare-Luna, Madison, WI; software Encore version 14.10). | pre and post intervention (i.e. 12 weeks) |
| 10-meter walk test | The volunteers will walk 10 meters. The gait speed will be evaluated (m/s). The test will be performed indoor, on a flat floor in a sports court. | pre and post intervention (i.e. 12 weeks) |
| 400-meter walk test | The volunteers will walk 400 meters. The gait speed will be evaluated (m/s). The test will be performed indoor, on a flat floor in a sports court. | pre and post intervention (i.e. 12 weeks) |
| 900-meter walk test | The volunteers will walk 900 meters. The gait speed will be evaluate (m/s). The test will be performed indoor, on a flat floor in a sports court. | pre and post intervention (i.e. 12 weeks) |
Quadriceps electromyography
| pre and post intervention (i.e. 12 weeks) |
| Physical activity level | The International Physical Activity Questionnaire short form (IPAQ) will be used to measure the level (time spent) of physical activities during the day. The questionnaire records the activity of four intensity levels: 1) vigorous-intensity activity such as aerobics, 2) moderate-intensity activity such as leisure cycling, 3) walking, and 4) sitting. The level of physical activity will be quantified by the sum of the four levels of intensity. | pre and post intervention (i.e. 12 weeks) |
| Evaluation the quality of life | The 36-Item Short Form Health Survey (SF-36) will be used to measure the overall quality of life aspects in the following domains: functional capacity, physical limitations, pain, overall health, vitality, social aspects, emotional limitations and mental health. | pre and post intervention (i.e. 12 weeks) |
| Self-report fatigue | The Brief Fatigue Inventory will be used for measured the self-report fatigue. | pre and post intervention (i.e. 12 weeks) |
| Cytokines | Blood samples (16 ml) will be collected between 7:30 AM and 9:00 AM after an overnight fast (10-12 hours). The blood samples (venous) will be collected by a dry tube with gel separator or EDTA (vacuum-sealed system; Vacutainer, England). The sample will be centrifuged for 10 minutes (3.000 rpm) and samples will be separated and stocked (-80 C) for futures analysis. The blood indicators will be measured (enzyme-linked immunosorbent assay method) with Touch equipment and R&D kits (USA). | pre and post intervention (i.e. 12 weeks) |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
| D008722 | Methods |
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