Additive Effect of Intravenous Acetaminophen on Postoperative Pain Control

Additive Effect of Intravenous Acetaminophen Administered at the End of Surgery on Postoperative Pain Control With Nefopam and Fentanyl-based Patient-controlled Analgesia: A Double-blind Randomized Controlled Trial

This study aimed to evaluate the additive effect of acetaminophen on postoperative pain control in patients receiving nefopam and fentanyl-based patient-controlled analgesia.

Participants undergoing laparoscopic hysterectomy will be randomly assigned to treatment group or control group. After end of surgery, acetaminophen or normal saline (placebo) will be administered intravenously depending on the group assigned.

Inclusion Criteria:

• Patients undergoing total laparoscopic hysterectomy due to uterine myoma, cervical cancer, endometriosis, uterine prolapse

Exclusion Criteria:

• Liver disease (aspartate transaminase OR alanine transaminase > 80 IU/L)
• Chronic kidney disease (GFR < 30 ml/min/1.73m2)
• History of drug allergy
• Chronic pain lasting more than 3 months
• Conversion to laparotomy
• Complex surgery (co-operation with colon surgeon or urologist)
• Limitation in expressing pain