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This study aimed to evaluate the additive effect of acetaminophen on postoperative pain control in patients receiving nefopam and fentanyl-based patient-controlled analgesia.
Participants undergoing laparoscopic hysterectomy will be randomly assigned to treatment group or control group. After end of surgery, acetaminophen or normal saline (placebo) will be administered intravenously depending on the group assigned.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment | Experimental | Patients in this group will receive 1 gram of acetaminophen intravenously after the end of surgery. |
|
| Control | No Intervention | Patients in this group will receive 100 ml of normal saline intravenously after the end of surgery. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acetaminophen | Drug | Acetaminophen will be intravenously administrated to treatment group after the end of surgery. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Total volume of administered analgesics during postoperative 24 hours | morphine equivalent dose of patient-controlled analgesics administered during first 24 hours after end of surgery | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Pain score | 11-point numeric rating scale ranging from '0' representing one pain extreme (e.g. "no pain") to '10' representing the other pain extreme (e.g. "pain as bad as you can imagine" or "worst pain imaginable") | 24 hours |
| Patient satisfaction score |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jin-Tae Kim, Pf. | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | 03080 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39979845 | Derived | Nam S, Yoo S, Park SK, Kim JT. Additive effect of a single intravenous dose of acetaminophen administered at the end of laparoscopic hysterectomy on postoperative pain control with nefopam and fentanyl-based patient-controlled analgesia: a double-blind, randomized controlled trial. BMC Anesthesiol. 2025 Feb 20;25(1):88. doi: 10.1186/s12871-025-02971-w. |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| D005831 | Genital Diseases, Female |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D000082 | Acetaminophen |
| D013812 | Therapeutics |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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Double-blind randomized controlled trial
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11-point numeric rating scale ranging from '0' representing one extreme (e.g. "extremely dissatisfied") to '10' representing the other extreme (e.g. "extremely satisfied") |
| 24 hours |
| Postoperative nausea and vomiting | 4-scales scoring (none; mild; moderate; severe) | 24 hours |
| Opioid-related adverse effect | Incidence of respiratory, gastrointestinal, and central nervous system complications | 24 hours |
| Use of alternative analgesics | Additional administration of other analgesics | 24 hours |
| Length of stay | Hospital length of stay | From date of hospital admission until the date of discharge, an average of 1 week |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
| Aniline Compounds |
| D000588 | Amines |