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Objective of the study
The main objectives of this project are:
The researchers will use a randomized, placebo controlled, counter-balanced, cross-over design.
Thirteen healthy subjects will visit the lab 3 times. On the first visit (familiarisation trial), the investigators will collect the participants' characteristics. The participants will also be familiarized to the procedures and materials of the experiment during this first visit. The second and third visit contain the experimental setup and will proceed as follows: first, the participants will fill in a mental fatigue scale (M-VAS) and motivation scale. Next, the subjects will carry out a functional test battery (hop test, vertical jump test, Y-balance test, and a balance reaction-time test). Session rate of perceived exertion (RPE) is measured to indicate how fatigued the participants feel because of the test battery; also, M-VAS is collected once more. Then, a short cognitive task (Flanker task) is followed by either a long intensive cognitive task (90 minutes Stroop task) or control task (90 minutes documentary). Afterwards, participants have to carry out the Flanker task, fill in M-VAS (2x), perform the same test battery, fill in session RPE and one final fatigue scale (Nasa TLX). Heart frequency and EEG will be measured continuously during the trials.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mental Fatigue Condition | Experimental |
| |
| Control Condition | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mental Fatigue | Other | modified stroop task |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Single-leg hop test | Single-leg hop test for distance performance | Change in single-leg hop test for distance performance: from baseline and 120 minutes after baseline (immediately after the flanker task) |
| Vertical jump test | Vertical jump height performance | Change in vertical jump height performance: from baseline and 120 minutes after baseline (immediately after the flanker task) |
| Y-balance test | Balance and reach performance; participants have to maintain their balance while reaching as far as possible along 3 different directions. | Change in Y-balance performance: from baseline and 120 minutes after baseline (immediately after the flanker task) |
| Balance-reaction time test | Balance and reaction time performance; participants have to maintain their balance while reacting as fast as possible in 3 different directions. | Change in balance and reaction time performance: from baseline and 120 minutes after baseline (immediately after the flanker task) |
| EEG power spectrum analysis | Brain activity during the Y-balance test, balance-reaction time test and flanker task will be registered at baseline and immediately after the flanker task | Change in EEG power spectrum: from baseline and 120 minutes after baseline (immediately after the flanker task) |
| Measure | Description | Time Frame |
|---|---|---|
| Mental fatigue Visual Analogue Scale (M-VAS) | Subjective measure of mental fatigue (0-10cm; 0 = no mental fatigue; 10 = maximal mental fatigue) | Change in M-VAS: at baseline, 20 min after baseline (immediately after the first test battery), 120 min after baseline (immediately after the second flanker task) and 135 min after baseline (immediately after the final test battery) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Vrije Universiteit Brussel | Brussels | 1050 | Belgium |
individual patient data will not be shared
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| ID | Term |
|---|---|
| D005222 | Mental Fatigue |
| ID | Term |
|---|---|
| D005221 | Fatigue |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001526 | Behavioral Symptoms |
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| Control |
| Other |
documentary |
|
| Flanker task | Objective measure of mental fatigue; reaction time and accuracy give an objective indication of mental fatigue | Change in flanker task: at baseline and 90 minutes after baseline (immediately after the mental fatiguing task) |
| 90-minute stroop task | 90 minutes mental fatiguing task; reaction time and accuracy give an objective indication of mental fatigue | Change in reaction time and accuracy will be assessed with a 90-min cognitive task; Reaction Time and Accuracy during the 90-min task will be reported as mean reaction time and accuracy during 8 blocks of 11min15sec |
| D001519 | Behavior |