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| Name | Class |
|---|---|
| Deutsche Krebshilfe e.V., Bonn (Germany) | OTHER |
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The understanding of acute lymphoblastic leukemia (ALL) in childhood and adolescence has largely changed due to extensive genetic research in recent years: ALL is now considered to be a very heterogeneous disease group. The leukemia cells present themselves with quite differently activated regulatory mechanisms of the malignant phenotype. The introduction of more accurate methods of assessing therapy response ("minimal residual disease [MRD] tests") has provided new insights into very different mechanisms of action, including factors influenced by host factors; this has had practical clinical consequences for the use of more individualized therapy. Multimodal therapies have enabled a cure level of over 80% for ALL in this age group. However, the own and international study data show that the therapy toxicity of the contemporary chemotherapy concepts has become unacceptably high, in particular with respect to those intensified therapies used for the treatment of patients at high risk of ALL relapse.
The AIEOP-BFM ALL 2017 study therefore aims for an innovative integrated approach that will not only adapt the risk stratification to new prognostic markers using more comprehensive diagnostics, but above all, qualitatively reorient the therapy. The most important consequence will be that this study is testing immunotherapy with the bispecific antibody blinatumomab as an alternative to particularly intensive and toxic chemotherapy elements in precursor B-cell ALL (pB-ALL) patients with detectable chemotherapy resistance and at high risk of relapse. With the aim to complement the effects of the conventional chemotherapy, Blinatumomab is in addition tested in the large group of pB-ALL patients at intermediate relapse risk with seemingly unremarkable leukemia, but who account for a large proportion of all relapses. Targeted therapy is also used in the form of the proteasome inhibitor bortezomib for patients with pB-ALL and slow response to the drugs of the induction chemotherapy with the aim to overcome intrinsic chemotherapy resistance of the ALL cells. In patients with T-lineage ALL, who have particularly poor chances for cure after relapse, the established consolidation chemotherapy has proved to be particularly effective. This chemotherapy phase is therefore tested in a longer and more intensive form in such T-ALL patients with intermediate or slow early treatment response with the aim to reduce the relapses rate in this subgroup.
Patients are stratified into 4 early risk groups for therapy during the consolidation phase (T/early SR, T/early non-SR, pB/early non-HR, pB/early HR) and 5 risk groups for post-consolidation therapy (T/non-HR, T/HR, pB/SR, pB/MR, pB/HR). Risk stratification is based on immunophenotypic lineage, genetics of leukemic cells and treatment response on the basis of cytomorphology and methods for detection minimal residual disease.
The trial includes four randomized study questions testing experimental treatments on top of the risk-stratified standard chemotherapy backbone:
Primary study questions:
Randomization R-eHR: Early High-risk (early HR) pB-ALL defined by genetics and/or inadequate treatment response over the course of induction: Can the probability of event-free survival (pEFS) from time of randomization be improved by additional therapy with the proteasome inhibitor bortezomib during an extended consolidation treatment phase compared with standard extended consolidation?
Randomization R-HR: High-risk (HR) pB-ALL defined by genetics and/or inadequate treatment response by the end of consolidation: Can the pEFS from time of randomization be improved by a treatment concept including two cycles of post-consolidation immunotherapy with blinatumomab (15 µg/m²/d for 28 days per cycle) plus 4 doses intrathecal Methotrexate replacing two conventional highly intensive chemotherapy courses?
Randomization R-MR: Intermediate risk (MR) pB-ALL defined by genetics and intermediate MRD response: Can the probability of disease-free survival (pDFS) from time of randomization be improved by additional therapy with one cycle of post-reintensification immunotherapy with blinatumomab (15 µg/m²/d for 28 days)?
Randomization R-T: Early non-standard risk (early non-SR) T-ALL patients defined by treatment response over the course of induction: Can the pEFS from time of randomization be improved by the extension of the standard of care consolidation phase by 14 days with an increase of the consolidation cumulative doses of Cyclophosphamide, Cytarabine and 6-Mercaptopurine by 50%?
Secondary study questions:
All randomizations: Can the overall survival be improved by the treatment in the experimental arm?
All randomizations: What is the incidence of treatment-related toxicities and mortality in the experimental arm compared to the standard arm?
Randomization R-eHR: Can the MRD load after consolidation treatment be reduced by the additional treatment with bortezomib?
Randomization R-HR: Can treatment-related life-threatening complications and mortality during the intensified consolidation phase of high-risk treatment be reduced when replacing two intensive chemotherapy courses by two cycles of immunotherapy with blinatumomab?
Randomization R-HR: What is the proportion of patients with insufficient MRD response to blinatumomab as defined in the protocol as compared to the MRD response after the HR-2' block in the control arm?
Randomization R-HR: Can the MRD load after the first treatment cycle (HR 2'/blinatumomab) and the second cycle (HR-3'/blinatumomab) be reduced in the experimental arm when compared with conventional intensive chemotherapy? Randomization R-MR: What is the proportion of patients with positive MRD after reintensification Protocol II who become MRD-negative over the blinatumomab cycle compared to 4 weeks of standard maintenance therapy?
Randomization R-T: Can the MRD load after consolidation treatment be reduced by extension of the consolidation phase?
Standard-risk patients: Is the clinical outcome comparable to that obtained for standard-risk patients in study AIEOP-BFM ALL 2009?
A small subgroup of patients at very high relapse risk is eligible for allogeneic hematopoietic stem cell transplantation after the intensified consolidation therapy phase.
Patients with T-ALL and hyperleukocytosis (>=100,000/µL) and patients with CNS involvement at diagnosis (CNS3 status) are eligible for cranial irradiation with 12 Gy if age at time of irradiation is at least 4 years.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| pB: early (non-)HR-standard/MR-standard | Active Comparator | Induction (5 wks): "Protocol IA" with prednisolone, vincristine, daunorubicin, pegaspargase, IT methotrexate (MTX) Consolidation (6 w/4 w): "Consolidation extended" (control arm of randomization R-eHR) with cyclophosphamide, cytarabine, 6-mercaptopurine (6-MP), IT MTX, dexamethasone, vincristine, pegaspargase or "Consolidation short" (standard arm of early non-HR group) with cyclophosphamide, cytarabine, 6-mercaptopurine, IT MTX Extra-compartment phase (8 wks): "Protocol M" with 6-MP, HD-MTX, IT MTX Reinduction (6 wks): "Protocol II" with dexamethasone, vincristine, doxorubicin, pegaspargase, IT MTX, cyclophosphamide, tioguanine, cytarabine Maintenance (until 2 years after initial diagnosis): 6-MP, MTX [without preceding blinatumomab (control arm of randomization R-MR)] Erwinase is given in case of allergy to pegaspargase. |
|
| pB: early HR-exp./MR-standard | Experimental | Induction (5 w): "Protocol IA" with prednisolone, vincristine, daunorubicin, pegaspargase, IT MTX Consolidation (6 w): "Consolidation extended+BZM" (experimental arm of randomization R-eHR) with cyclophosphamide, cytarabine, 6-MP, IT MTX, dexamethasone, vincristine, pegaspargase, bortezomib (given at 1.3 mg/m²/dose on days 50, 53, 56 and 59) Extra-compartment phase (8 wks): "Protocol M" with 6-MP, HD-MTX, IT MTX Reinduction (6 wks): "Protocol II" with dexamethasone, vincristine, doxorubicin, pegaspargase, IT MTX, cyclophosphamide, tioguanine, cytarabine Maintenance (until 2 yrs after initial diagnosis): 6-MP, MTX [without preceding blinatumomab (control arm of randomization R-MR)] Erwinase is given in case of allergy to pegaspargase. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blinatumomab | Drug | Experimental therapy in randomizations R-HR and R-MR |
|
| Measure | Description | Time Frame |
|---|---|---|
| Event-free survival | Randomization R-eHR, R-HR and R-T: Time from randomization until the first event defined as follow: cytomorphological or molecular non-response (resistance to protocol treatment, considered as event at day zero), relapse, second malignancy or death from any cause. This will be called EFS time. | Assessed up to 120 months from start of study |
| Disease-free survival | Randomization R-MR: Time from randomization until the first event defined as follow: Relapse, second malignancy or death from any cause. This will be called DFS time. | Assessed up to 120 months from start of study |
| Measure | Description | Time Frame |
|---|---|---|
| Survival | All patients/randomizations: Time until death from any cause, starting at the same time point as the EFS/DFS. | Assessed up to 120 months from start of study |
| Treatment-related mortality |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anja Möricke, MD | Contact | +4943150020150 | a.moericke@pediatrics.uni-kiel.de | |
| Lile Bauer | Contact | +4943150020152 | lile.bauer@uksh.de |
| Name | Affiliation | Role |
|---|---|---|
| Martin Schrappe, MD | Department of Pediatrics, University Hospital of Schleswig-Holstein, Campus Kiel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sydney Children's Hospital | Recruiting | Sydney | Australia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41671463 | Derived | Davis KL, Yao CC, Zimmerman JAO, Rau RE. Immunotherapy in B-Cell Acute Lymphoblastic Leukemia. J Natl Compr Canc Netw. 2025 Dec;23(12):e257067. doi: 10.6004/jnccn.2025.7067. | |
| 38841802 | Derived | Domka K, Dabkowska A, Janowska M, Urbanska Z, Pastorczak A, Winiarska M, Fidyt K, Lachota M, Patkowska E, Sedek L, Perkowski B, Hunia J, Jakubowska J, Krzymieniewska B, Lech-Maranda E, Mlynarski W, Szczepanski T, Firczuk M. Asciminib stands out as the superior tyrosine kinase inhibitor to combine with anti-CD20 monoclonal antibodies for the treatment of CD20+ Philadelphia-positive B-cell precursor acute lymphoblastic leukemia in preclinical models. Haematologica. 2024 Nov 1;109(11):3520-3532. doi: 10.3324/haematol.2023.284853. |
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pB-ALL/MR: 2 parallel groups (R-MR) or 2x2 factorial design (R-eHR, R-MR) depending on early risk group assignment.
pB-ALL/HR: 2 parallel groups (R-HR) or 2x2 factorial design (R-eHR, R-HR) depending on early risk group assignment.
T-ALL/early non-SR: 2 parallel groups (R-T).
pB-ALL/SR: Single group.
T-ALL/early SR: Single group.
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| pB: early (non)HR-standard/MR-exp. | Experimental | Induction (5 w): "Protocol IA" with prednisolone, vincristine, daunorubicin, pegaspargase, IT MTX Consolidation (6 w/4 w): "Consolidation extended" (control arm in randomization R-eHR) with cyclophosphamide, cytarabine, 6-MP, IT MTX, dexamethasone, vincristine, pegaspargase or "Consolidation short" (standard arm of early non-HR group) with cyclophosphamide, cytarabine, 6-mercaptopurine, IT MTX Extra-compartment phase (8 w): "Protocol M" with 6-MP, HD-MTX, IT MTX Reinduction (6 w): "Protocol II" with dexamethasone, vincristine, doxorubicin, pegaspargase, IT MTX, cyclophosphamide, tioguanine, cytarabine Blinatumomab (4 w): 1 cycle blinatumomab given at 15 µg/m²/day for 28 days (experimental arm of randomization R-MR) Maintenance (until 2 yrs after initial diagnosis): 6-MP, MTX Erwinase is given in case of allergy to pegaspargase. |
|
| pB: early HR-exp./MR-exp. | Experimental | Induction (5 w): "Protocol IA" with prednisolone, vincristine, daunorubicin, pegaspargase, IT MTX Consolidation (6 w): "Consolidation extended+BZM" (experimental arm of randomization R-eHR) with cyclophosphamide, cytarabine, 6-MP, IT MTX, dexamethasone, vincristine, pegaspargase, bortezomib (given at 1.3 mg/m²/dose on days 50, 53, 56 and 59) Extra-compartment phase (8 w): "Protocol M" with 6-MP, HD-MTX,IT MTX Reinduction (6 weeks): "Protocol II" with dexamethasone, vincristine, doxorubicin, PEG-L-asparaginase, IT MTX, cyclophosphamide, tioguanine, cytarabine Blinatumomab (4 w): 1 cycle blinatumomab given at 15 µg/m²/day for 28 days (experimental arm of randomization R-MR) Maintenance phase (until 2 yrs after initial diagnosis): 6-MP, MTX Erwinase is given in case of allergy to pegaspargase. |
|
| pB: early (non-)HR-standard/HR-standard | Active Comparator | Induction (5 w): as in other pB arms Consolidation (6 w/4 w): "Consolidation extended" (control arm in randomization R-eHR) with cyclophosphamide, cytarabine, 6-MP, IT methotrexate, dexamethasone, vincristine, pegaspargase or "Consolidation short" (standard arm of early non-HR group) with cyclophosphamide, cytarabine, 6-MP, IT MTX Intensified consolidation (3x5 d): Block HR-1' followed by HR-2' and HR-3' (control arm in randomization R-HR) with dexamethasone, vincristine, vindesine, daunorubicin, HD-MTX, IT MTX, HD-cytarabine, cyclophosphamide, ifosfamide, pegaspargase, etoposide Reinduction (3x4 w): "Protocol III" given 3 times with dexamethasone, vincristine, doxorubicin, pegaspargase, IT MTX, cyclophosphamide, tioguanine, cytarabine Maintenance (until 2 yrs after init. diagnosis): 6-MP, MTX Erwinase is given in case pegaspargase allergy. Pts with poor response to intensified consolidation receive Myocet-FLA (Myocet, fludarabine, HD-cytarabine, IT-MTX). |
|
| pB: early HR-exp./HR-standard | Experimental | Induction (5 w): as in other pB arms Consolidation (6 w): "Consolidation extended+BZM" (experimental arm of randomization R-eHR) with cyclophosphamide, cytarabine, 6-MP, IT MTX, dexamethasone, vincristine, pegaspargase, bortezomib (1.3 mg/m²/dose on days 50, 53, 56 and 59) Intensified consolidation (3x5 d): Block HR-1' followed by HR-2' and HR-3' (control arm in randomization R-HR) with dexamethasone, vincristine, vindesine, daunorubicin, HD-MTX, IT MTX, HD-cytarabine, cyclophosphamide, ifosfamide, pegaspargase, etoposide Reinduction (3x4 w): as in arm "pB: early (non-)HR-standard/HR-standard" Maintenance (until 2 yrs after initial diagnosis): 6-MP, MTX Erwinase is given in case of allergy to pegaspargase. Pts with poor response to intensified consolidation receive Myocet-FLA (Myocet, fludarabine, HD-cytarabine, IT-MTX) |
|
| pB: early (non-)HR-standard/HR-exp. | Experimental | Induction (5 w): as in other pB arms Consolidation (6 w/4 w): "Consolidation extended" (control arm in randomization R-eHR) with cyclophosphamide, cytarabine, 6-MP, IT MTX, dexamethasone, vincristine, pegaspargase or "Consolidation short" (standard arm of early non-HR group) with cyclophosphamide, cytarabine, 6-MP, IT MTX Intensified consolidation (1x5 d + 2x28 d): Block HR-1' with dexamethasone, vincristine, HD-MTX, IT MTX, HD-cytarabine, cyclophosphamide, pegaspargase followed by 2 cycles blinatumomab at 15 µg/m²/day for 28 days per cycle plus 2x2 doses IT MTX (experimental arm of randomization R-HR) Reinduction (3x4 weeks): as in arm "pB: early (non-)HR-standard/HR-standard" Maintenance (until 2 yrs after init. diagnosis): 6-MP, MTX Erwinase is given in case of pegaspargase allergy. Pts with poor response to intensified consolidation receive Myocet-FLA (Myocet, fludarabine, HD-cytarabine, IT-MTX) |
|
| pB: early HR-exp./HR-exp. | Experimental | Induction (5 w): as in other pB arms Consolidation (6 w): "Consolidation extended+BZM" (experimental arm of randomization R-eHR) with cyclophosphamide, cytarabine, 6-MP, IT MTX, dexamethasone, vincristine, pegaspargase, bortezomib (1.3 mg/m²/dose on days 50, 53, 56 and 59) Intensified consolidation (1x5 d + 2x28 d): Block HR-1' with dexamethasone, vincristine, HD-MTX, IT MTX, HD-cytarabine, cyclophosphamide, pegaspargase followed by 2 cycles blinatumomab at 15 µg/m²/day for 28 days per cycle plus 2x2 doses IT MTX (experimental arm of randomization R-HR) Reinduction (3x4 weeks): as in arm "pB: early (non-)HR-standard/HR-standard" Maintenance (until 2 yrs after initial diagnosis): 6-MP, MTX Erwinase is given in case of allergy to pegaspargase. Pts with poor response to intensified consolidation receive Myocet-FLA (Myocet, fludarabine, HD-cytarabine, IT-MTX) |
|
| pB: early non-HR/SR | Other | Induction (5 w): "Protocol IA" with prednisolone, vincristine, daunorubicin, pegaspargase, IT MTX Consolidation (4 w): "Consolidation short" with cyclophosphamide, cytarabine, 6-mercaptopurine, IT MTX Extra-compartment phase (8 w): "Protocol M" with 6-MP, HD-MTX, IT MTX Reinduction (6 w): "Protocol II" with dexamethasone, vincristine, doxorubicin, pegaspargase, IT MTX, cyclophosphamide, tioguanine, cytarabine Maintenance (until 2 yrs after initial diagnosis): 6-MP, MTX Erwinase is given in case of allergy to pegaspargase. |
|
| T: early non-SR-standard/(non-)HR | Active Comparator | Induction (5 w): "Protocol IA-Dexa" with prednisolone/dexamethasone, vincristine, daunorubicin, pegaspargase, IT MTX or "Protocol IA-CPM" with prednisolone instead of dexamethasone and additional CPM Consolidation (4 w): "Protocol IB regular" (control arm in randomization. R-T) with cyclophosphamide, cytarabine, 6-mercaptopurine, IT MTX non-HR extra-compartment phase and reinduction: as in arm "pB: early non-HR/SR" HR intensified consolidation and reinduction: as in arm "pB: early (non-)HR-standard/HR-standard" Maintenance (until 2 yrs after initial diagnosis): 6-MP, MTX Erwinase is given in case of allergy to pegaspargase. Pts with poor response to intensified consolidation receive Myocet-FLA (Myocet, fludarabine, HD-cytarabine, IT-MTX) |
|
| T: early non-SR-exp/(non-)HR | Experimental | Induction (5 w): "Protocol IA-Dexa" with prednisolone/dexamethasone, vincristine, daunorubicin, pegaspargase, IT MTX or "Protocol IA-CPM" with prednisolone instead of dexamethasone and additional CPM Consolidation (6 w): "Protocol IB long" (experimental arm in randomization R-T) with cyclophosphamide, cytarabine, 6-mercaptopurine, IT MTX non-HR extra-compartment phase and reinduction: as in arm "pB: early non-HR/SR" HR intensified consolidation and reinduction: as in arm "pB: early (non-)HR-standard/HR-standard" Maintenance (until 2 yrs after initial diagnosis): 6-MP, MTX Erwinase is given in case of allergy to pegaspargase. Pts with poor response to intensified consolidation receive Myocet-FLA (Myocet, fludarabine, HD-cytarabine, IT-MTX) |
|
| T: early SR/non-HR | Other | Induction (5 w): "Protocol IA-Dexa" with prednisolone/dexamethasone, vincristine, daunorubicin, pegaspargase, IT MTX Consolidation (4 w): "Protocol IB regular" with cyclophosphamide, cytarabine, 6-mercaptopurine, IT MTX Extra-compartment phase (8 w): "Protocol M" with 6-MP, HD-MTX, IT MTX Reinduction (6 w): "Protocol II" with dexamethasone, vincristine, doxorubicin, pegaspargase, IT MTX, cyclophosphamide, tioguanine, cytarabine Maintenance (until 2 yrs after initial diagnosis): 6-MP, MTX Erwinase is given in case of allergy to pegaspargase. |
|
| Bortezomib | Drug | Experimental therapy in randomization R-eHR |
|
| Cyclophosphamide | Drug | Part of standard chemotherapy and included in experimental treatment phase Protocol IB long in randomization R-T |
|
| Cytarabine | Drug | Part of standard chemotherapy and included in experimental treatment phase Protocol IB long in randomization R-T and in the intensification block Myocet-FLA for patients with very high relapse risk |
|
| Daunorubicin | Drug | Part of standard chemotherapy |
|
| Myocet | Drug | Part of intensification block Myocet-FLA for patients with very high relapse risk |
|
| Dexamethasone | Drug | Part of standard chemotherapy |
|
| Doxorubicin | Drug | Part of standard chemotherapy |
|
| Etoposide | Drug | Part of standard chemotherapy |
|
| Fludarabine Phosphate | Drug | Part of intensification block Myocet-FLA for patients with very high relapse risk |
|
| Ifosfamide | Drug | Part of standard chemotherapy |
|
| 6-Mercaptopurine | Drug | Part of standard chemotherapy and included in experimental treatment phase Protocol IB long in randomization R-T |
|
| Methotrexate | Drug | Part of standard chemotherapy |
|
| Pegaspargase | Drug | Part of standard chemotherapy |
|
| Prednisolone | Drug | Part of standard chemotherapy |
|
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| Tioguanin | Drug | Part of standard chemotherapy |
|
| Vincristine | Drug | Part of standard chemotherapy |
|
| Vindesine | Drug | Part of standard chemotherapy |
|
| Erwinase | Drug | Part of standard chemotherapy as substitute for PEG-L-Asparaginase in case of allergic reaction |
|
Frequency and incidence of treatment-related mortality in induction or continuous complete remission
| Assessed up to 120 months from start of study |
| Adverse Events of interest/Serious Adverse Events | Frequency and incidence of adverse events of interest and serious adverse events in specific protocol phases, randomized arms and overall during follow-up | Assessed up to 120 months from start of study |
| MRD response | MRD load after the randomized treatment phases (R-eHR, R-HR, R-MR and R-T) as well as after the first/second cycle of Blinatumomab or after the HR 2'/HR 3' block (R-HR) | Measurements of MRD response at end of randomized treatments (intended time frame 13 weeks in R-eHR/R-T, 26 weeks in R-HR, 34 weeks in R-MR). |
| Proportion of patients with Blina Poor-Response | Proportion of patients with poor MRD response to the first Blinatumomab cycle ("Blinatumomab Poor-Response") (R-HR) | Measurements of MRD response intended after 30 weeks from individual start of treatment, assessment of proportion at 120 months from start of study |
| The Children's Hospital at Westmead | Recruiting | Westmead | Australia |
|
| Univ.Klinik für Kinder- und Jugendheilkunde Graz | Recruiting | Graz | Austria |
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| Univ.Klinik für Kinder- und Jugendheilkunde Innsbruck | Recruiting | Innsbruck | Austria |
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| Kepler Universitätsklinikum | Recruiting | Linz | Austria |
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| LKH Salzburg | Recruiting | Salzburg | Austria |
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| St. Anna Kinderspital | Recruiting | Vienna | Austria |
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| University Hospital Brno | Recruiting | Brno | Czechia |
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| Regional Hospital České Budějovice | Recruiting | České Budějovice | Czechia |
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| University Hospital Hradec Králové | Recruiting | Hradec Králové | Czechia |
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| University Hospital Olomouc | Recruiting | Olomouc | Czechia |
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| University Hospital Ostrava-Poruba | Recruiting | Ostrava-Poruba | Czechia |
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| University Hospital Plzeň | Recruiting | Pilsen | Czechia |
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| University Hospital Motol | Recruiting | Prague | Czechia |
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| Masaryk´s Hospital Ústí nad Labem | Recruiting | Ústí nad Labem | Czechia |
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| Kinderklinik der med. Fakultät der RWTH, Bereich Hämatologie/Onkologie | Recruiting | Aachen | 52074 | Germany |
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| I. Klinik für Kinder u. Jugendliche, Klinikum Augsburg, Hämatologie/ Onkologie | Recruiting | Augsburg | 86156 | Germany |
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| Klinikum Berlin-Buch II. Kinderklinik, Bereich Onkologie/Allg. Pädiatrie | Recruiting | Berlin | 13125 | Germany |
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| Kinderklinik der Charité, Campus Virchow Klinikum (CVK), Abt.: Kinderhämatologie | Recruiting | Berlin | 13353 | Germany |
|
| Städtisches Krankenhaus, Kinderklinik | Recruiting | Braunschweig | 38118 | Germany |
|
| Klinikum Chemnitz gGmbH, Klinik für Kinder- und Jugendmedizin, Hämatologie / Onkologie | Recruiting | Chemnitz | 09009 | Germany |
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| Kliniken der Stadt Köln GmbH, Kinderkrankenhaus Riehl | Recruiting | Cologne | 50735 | Germany |
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| Med. Einrichtungen der Universität zu Köln, Klinik für Allg. Kinderheilkunde, Onkologisch-hämatologische Station | Recruiting | Cologne | 50937 | Germany |
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| Carl-Thiem-Klinikum, Kinderklinik, Abt. Hämatologie/Onkologie | Recruiting | Cottbus | 03048 | Germany |
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| Vestische Kinder- u. Jugendklinik, Universitätsklinik Witten/Herdecke | Recruiting | Datteln | 45711 | Germany |
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| Klinikum Dortmund, Klinik f. Kinder- und Jugendmedizin | Recruiting | Dortmund | 44137 | Germany |
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| Universitatsklinikum Carl Gustav Carus | Recruiting | Dresden | D-01307 | Germany |
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| Universitätsklinik | Recruiting | Düsseldorf | Germany |
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| Helios Klinikum Erfurt GmbH, Klinik für Kinderheilkunde | Recruiting | Erfurt | 99089 | Germany |
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| Universitaets - Kinderklinik | Recruiting | Erlangen | 91054 | Germany |
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| Universitaetsklinikum Essen | Recruiting | Essen | D-45147 | Germany |
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| Klinikum der J.W. Goethe Universitaet | Recruiting | Frankfurt | D-60590 | Germany |
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| Universitaetskinderklinik - Universitaetsklinikum Freiburg | Recruiting | Freiburg im Breisgau | D-79106 | Germany |
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| Klinikum der Justus-Liebig-Universität, Zentrum für Kinderheilkunde, Abt. Hämatologie/Onkologie | Recruiting | Giessen | 35385 | Germany |
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| Universitäts-Kinderklinik Päd. I, Hämatologie/Onkologie | Recruiting | Göttingen | 37099 | Germany |
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| Klinik und Poliklinik für Kinder und Jugendmedizin, Allgemeine Pädiatrie mit Poliklinik/Pädiatrische Onkologie und Hämatologie | Recruiting | Greifswald | 17475 | Germany |
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| Medizinische Hochschule Hannover, Zentrum Kinderheilkunde u. Jugendmedizin | Recruiting | Hanover | 30625 | Germany |
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| Universitäts-Kinderklinik, Päd. Onkologie, Hämatologie, und Immunologie | Recruiting | Heidelberg | 69120 | Germany |
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| Klinikum Heilbronn GmbH, Klinik für Kinderheilkunde und Jugendmedizin/Perinatalzentrum | Recruiting | Heilbronn | 74078 | Germany |
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| Gemeinschaftskrankenhaus Herdecke, Kinderabteilung | Recruiting | Herdecke | 58313 | Germany |
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| Universitaetsklinikum des Saarlandes | Recruiting | Homburg | 66421 | Germany |
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| Klinikum, der Friedrich-Schiller-Universität, Klinik für Kinder- und Jugendmedizin | Recruiting | Jena | 7740 | Germany |
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| Staedtisches Klinikum Karlsruhe gGmbH | Recruiting | Karlsruhe | 76133 | Germany |
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| Klinikum Kassel | Recruiting | Kassel | D-34125 | Germany |
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| Klinik für Allgemeine Paediatrie, Univ.-Klinikum Schleswig-Holstein, Campus Kiel | Recruiting | Kiel | 24105 | Germany |
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| Department für Frauen- und Kindermedizin, Abteilung für Pädiatrische Onkologie, Hämatologie und Hämostaseologie | Recruiting | Leipzig | 04103 | Germany |
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| Universität zu Lübeck, Klinik für Kinder- u. Jugendmedizin, Abt. Hämatologie/ Onkologie/Immunologie | Recruiting | Lübeck | 23538 | Germany |
|
| Universitätsklinikum Magdeburg, Klinik für Päd. Hämatologie/Onkologie | Recruiting | Magdeburg | 39120 | Germany |
|
| Klinikum Mannheim gGmbH, Kinderklinik, Abt. Hämatologie/Onkologie | Recruiting | Mannheim | 68167 | Germany |
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| Universitätsklinikum | Recruiting | Mannheim | Germany |
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| Johannes Wesling Klinikum Minden | Recruiting | Minden | 32429 | Germany |
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| Städt. Krankenhaus München GmbH, Krankenhaus München-Schwabingen, Kinderklinik d. TU | Recruiting | München | 80804 | Germany |
|
| Ludwig-Maximilian-Universität, Dr. von Haunersches Kinderspital | Recruiting | München | Germany |
|
| Universitäts-Kinderklinik, Päd. Hämatologie und Onkologie | Recruiting | Münster | 48149 | Germany |
|
| Cnopf'sche Kinderklinik, Onkologie | Recruiting | Nuremberg | 90419 | Germany |
|
| Klinikum Oldenburg gGmbH, Zentrum für Kinder- u. Jugendmedizin, (Elisabeth Kinderkrankenhaus) | Recruiting | Oldenburg | 26133 | Germany |
|
| Universitätsklinikum | Recruiting | Regensburg | Germany |
|
| Universitäts-Kinderklinik | Recruiting | Rostock | 18055 | Germany |
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| Asklepios-Klinik, Sankt Augustin GmbH | Recruiting | Sankt Augustin | 53757 | Germany |
|
| HELIOS Kliniken Schwerin, Klinik f. Kinder-u. Jugendmedizin | Recruiting | Schwerin | 19049 | Germany |
|
| Olga-Hospital, Kinderklinik, Pädiatrisches Zentrum, Abt. Hämatologie/Onkologie | Recruiting | Stuttgart | 70176 | Germany |
|
| Krankenanstalt Trier, Mutterhaus der Borromaeerinnen, Pädiatrische Abteilung | Recruiting | Trier | 54290 | Germany |
|
| Universitaetsklinikum Tuebingen | Recruiting | Tübingen | D-72076 | Germany |
|
| Comprehensive Cancer Center Ulm at Universitaetsklinikum Ulm | Recruiting | Ulm | D-89075 | Germany |
|
| Stadtkrankenhaus, Kinderklinik | Recruiting | Wolfsburg | 38440 | Germany |
|
| Universitaets - Kinderklinik Wuerzburg | Recruiting | Würzburg | D-97080 | Germany |
|
| Soroka University Medical Center | Recruiting | Beersheba | Israel |
|
| Rambam Health Care Campus | Recruiting | Haifa | Israel |
|
| Hadassah Medical center | Recruiting | Jerusalem | Israel |
|
| Schneider Children Medical Center of Israel | Recruiting | Petah Tikva | Israel |
|
| Sheba Medical Center Tel-Hashomer | Recruiting | Ramat Gan | Israel |
|
| Dana children hospital | Recruiting | Tel Aviv | Israel |
|
| Azienda ospedali riuniti | Recruiting | Ancona | Italy |
|
| AOUC Policlinico Bari | Recruiting | Bari | Italy |
|
| A.O. Papa Giovanni XXIII | Recruiting | Bergamo | Italy |
|
| Università di Bologna | Recruiting | Bologna | Italy |
|
| ASST Spedali Civili di Brescia | Recruiting | Brescia | Italy |
|
| Ospedale Businco | Recruiting | Cagliari | Italy |
|
| Azienda ospedaliero universitaria | Recruiting | Catania | Italy |
|
| AO Pugliese Ciaccio | Recruiting | Catanzaro | Italy |
|
| S.O. Annunziata - A. O. Cosenza | Recruiting | Cosenza | Italy |
|
| Ospedale Meyer | Recruiting | Florence | Italy |
|
| Istituto Giannina Gaslini | Recruiting | Genova | Italy |
|
| Policlinico di Modena Azienda Ospedaliero-Universitaria | Recruiting | Modena | Italy |
|
| Clinica pediatrica Fondazione MBBM | Recruiting | Monza | Italy |
|
| A.O.U. Vanvitelli | Recruiting | Naples | Italy |
|
| AORN Santobono Pausilipon | Recruiting | Naples | Italy |
|
| Azienda ospedaliera di Padova | Recruiting | Padova | Italy |
|
| Ospedale Civico ARNAS Civico e Di Cristina | Recruiting | Palermo | Italy |
|
| Azienda ospedaliero-universitaria di Parma | Recruiting | Parma | Italy |
|
| Fondazione IRCCS Policlinico San Matteo | Recruiting | Pavia | Italy |
|
| Ospedale S. Maria della misericordia | Recruiting | Perugia | Italy |
|
| Ospedale Civile di Pescara | Recruiting | Pescara | Italy |
|
| Ospedale Santa Chiara Pisa | Recruiting | Pisa | Italy |
|
| Grande ospedale metropolitano B-M-M | Recruiting | Reggio Calabria | Italy |
|
| Ospedale infermi | Recruiting | Rimini | Italy |
|
| Fondazione Policlinico Gemelli | Recruiting | Roma | Italy |
|
| Ospedale Bambino Gesù | Recruiting | Roma | Italy |
|
| Policlinico Umberto I Università Sapienza di Roma | Recruiting | Roma | Italy |
|
| Ospedale "Casa sollievo della sofferenza" | Recruiting | San Giovanni Rotondo | Italy |
|
| A.O.U. Città della salute e della scienza di Torino | Recruiting | Torino | Italy |
|
| IRCCS Burlo Garofolo | Recruiting | Trieste | Italy |
|
| AOU Verona | Recruiting | Verona | Italy |
|
| Klinika pediatrickej hematológie a onkológie SZU a DFNsP | Recruiting | Banská Bystrica | Slovakia |
|
| Comenius University Children's Hospital | Recruiting | Bratislava | Slovakia |
|
| Detská fakultná nemocnica Košice | Recruiting | Košice | Slovakia |
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| Kantonsspital Aarau | Recruiting | Aarau | Switzerland |
|
| Universitäts-Kinderspital beider Basel | Recruiting | Basel | Switzerland |
|
| Ospedale San Giovanni Bellinzona | Recruiting | Bellinzona | Switzerland |
|
| Inselspital Bern | Recruiting | Bern | Switzerland |
|
| HUG Hôpitaux Universitaires de Gèneve | Recruiting | Geneva | Switzerland |
|
| CHUV Centre Hospitalier Universitaire Vaudois | Recruiting | Lausanne | Switzerland |
|
| Luzerner Kantonsspital-Kinderspital Luzern | Recruiting | Lucerne | Switzerland |
|
| Ostschweizer Kinderspital | Recruiting | Sankt Gallen | Switzerland |
|
| Universitäts-Kinderspital Zürich | Recruiting | Zurich | Switzerland |
|
| 35129146 | Derived | Tufekci O, Evim MS, Gunes AM, Celkan T, Karapinar DY, Kaya Z, Baysal B, Baytan B, Kocak U, Yilmaz S, Cinar S, Oren H. Assessment of Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia: A Multicenter Study From Turkey. J Pediatr Hematol Oncol. 2022 Mar 1;44(2):e396-e402. doi: 10.1097/MPH.0000000000002419. |
| ID | Term |
|---|---|
| D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
| ID | Term |
|---|---|
| D007945 | Leukemia, Lymphoid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| C510808 | blinatumomab |
| D000069286 | Bortezomib |
| D003520 | Cyclophosphamide |
| D003561 | Cytarabine |
| D003630 | Daunorubicin |
| D004317 | Doxorubicin |
| D003907 | Dexamethasone |
| D005047 | Etoposide |
| C042382 | fludarabine phosphate |
| D007069 | Ifosfamide |
| D015122 | Mercaptopurine |
| D008727 | Methotrexate |
| C042705 | pegaspargase |
| D011239 | Prednisolone |
| D011241 | Prednisone |
| D013866 | Thioguanine |
| D014750 | Vincristine |
| D014751 | Vindesine |
| D001215 | Asparaginase |
| ID | Term |
|---|---|
| D001897 | Boronic Acids |
| D000148 | Acids, Noncarboxylic |
| D000143 | Acids |
| D007287 | Inorganic Chemicals |
| D001896 | Boron Compounds |
| D009930 | Organic Chemicals |
| D011719 | Pyrazines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D010752 | Phosphoramide Mustards |
| D009588 | Nitrogen Mustard Compounds |
| D009150 | Mustard Compounds |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D063088 | Phosphoramides |
| D009943 | Organophosphorus Compounds |
| D003562 | Cytidine |
| D011741 | Pyrimidine Nucleosides |
| D011743 | Pyrimidines |
| D001087 | Arabinonucleosides |
| D009705 | Nucleosides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
| D018943 | Anthracyclines |
| D009279 | Naphthacenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D011083 | Polycyclic Compounds |
| D000617 | Aminoglycosides |
| D006027 | Glycosides |
| D002241 | Carbohydrates |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D013259 | Steroids, Fluorinated |
| D011034 | Podophyllotoxin |
| D013764 | Tetrahydronaphthalenes |
| D009281 | Naphthalenes |
| D005960 | Glucosides |
| D010078 | Oxazines |
| D013438 | Sulfhydryl Compounds |
| D013457 | Sulfur Compounds |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D000630 | Aminopterin |
| D011622 | Pterins |
| D011621 | Pteridines |
| D011244 | Pregnadienediols |
| D014748 | Vinca Alkaloids |
| D046948 | Secologanin Tryptamine Alkaloids |
| D026121 | Indole Alkaloids |
| D000470 | Alkaloids |
| D007211 | Indoles |
| D054836 | Indolizidines |
| D007212 | Indolizines |
| D000581 | Amidohydrolases |
| D006867 | Hydrolases |
| D004798 | Enzymes |
| D045762 | Enzymes and Coenzymes |
Not provided
Not provided