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Studies have shown that the risk of developing heart arrhythmias, is increased in patients receiving medication for Attention-deficit hyperactivity disorder (ADHD) and depression. The QT-interval on a electrocardiogram (ECG) is often used to assess the patients risk of developing heart arrhythmias. The QT-interval defines the hearts electrical resting period and a long interval is linked to an increased risk of developing heart arrhythmias. In this project the investigators wish to examine possible side-effects in patients receiving medication for ADHD and depression and their dynamic QT-interval changes, by analysing the ECG changes that occur during "Brisk Standing".
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Methylphenidate-Group | The group is examined before and after intake of Methylphenidate |
| |
| Methylphenidate and know QT-prolonging SSRI | The group is examined before and after intake of Methylphenidate |
| |
| Methylphenidate and non-QT-prolonging SSRI | The group is examined before and after intake of Methylphenidate |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Electrocardiogram examination | Diagnostic Test | 12-lead ECG monitored by Holter |
|
| Measure | Description | Time Frame |
|---|---|---|
| ECG changes | The Primary Outcome assess whether there are changes on ECG, primary the QTc-interval, in participants receiving medication for ADHD and depression. | Through study completion, an average of 1 year. |
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Inclusion Criteria:
Exclusion Criteria:
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50 Patients treated with Methylphenidate 50 Patients treated with Methylphenidate and QT-prolonging SSRI 50 Patients treated with Methylphenidate and a non QT-prolonging SSRI
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Herlev Hospital | Herlev | 2730 | Denmark |
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| Echocardiography | Diagnostic Test | Echocardiography in accordance to Danish Society of Cardiology |
|
| Blood Samples | Procedure | Blood Samples include, Genetic analysis, serum-Methylphenidate, serum-Citalopram. Sodium, Potassium, Magnesium, Calcium, Chloride, White-Blood-Count, Hemoglobin, C-reactive-Protein, Creatinine, Carbamide, aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), Glucose and pro-brain natriuretic peptide (Pro-BNP). |
|
| Questionnaire | Behavioral | Questionnaire regarding patients quality of life |
|
| ID | Term |
|---|---|
| D008133 | Long QT Syndrome |
| D001289 | Attention Deficit Disorder with Hyperactivity |
| D003863 | Depression |
| D003643 | Death |
| D016757 | Death, Sudden, Cardiac |
| D029597 | Romano-Ward Syndrome |
| D010335 | Pathologic Processes |
| D006323 | Heart Arrest |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D003645 | Death, Sudden |
| D001145 | Arrhythmias, Cardiac |
| D006330 | Heart Defects, Congenital |
| D018376 | Cardiovascular Abnormalities |
| D000013 | Congenital Abnormalities |
| D030342 | Genetic Diseases, Inborn |
| D001523 | Mental Disorders |
| ID | Term |
|---|---|
| D000075224 | Cardiac Conduction System Disease |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019958 | Attention Deficit and Disruptive Behavior Disorders |
| D065886 | Neurodevelopmental Disorders |
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D004452 | Echocardiography |
| D001800 | Blood Specimen Collection |
| D011795 | Surveys and Questionnaires |
| ID | Term |
|---|---|
| D057791 | Cardiac Imaging Techniques |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D014463 | Ultrasonography |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
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