Central and Peripheral Adiposity and Iron Absorption

Relation Btw Adiposity, Inflammation & Iron Absorption:Comparison Btw Central & Peripheral Adiposity

Adiposity is a state of sub-clinical inflammation, thus hepcidin is increased in adiposity, often leading to iron deficiency in this population group. Central adiposity is generally considered having a greater negative effect on health compared to peripheral adiposity. Whether this can be also seen in hepcidin and thereby in iron absorption is uncertain.

Inclusion Criteria:

• either normal-weight (BMI 18-25kg/m2) or overweight/obese (BMI 28-50kg/m2) with either central or peripheral fat deposits based on DEXA

Exclusion Criteria:

• Iron Supplement or antibiotic intake within 2 weeks before study start
• diagnosed chronic disease or gastrointestinal disorders
• regular use of medication (except contraceptives)
• pregnancy
• lactation
• smoking
• blood donation or surgery within the last 4 months.