Risk Prediction for Alzheimer Dementia With Brain Imaging and Genetics

Risk Prediction for Alzheimer Dementia With Brain Imaging and Genetics

The purpose of this study is to learn about how trauma, posttraumatic stress disorder (PTSD), and mild traumatic brain injury that can occur during deployment affect the brain. The investigators also want to learn how PTSD and mild traumatic brain injury can affect the chance of developing Alzheimer disease later in life. The investigators will study this by using magnetic resonance imaging and positron emission tomography scans to obtain pictures of the brain.

Inclusion Criteria:

• Age 18 to 65
• Previously enrolled in studies of OEF/OIF veterans by the same investigators
• Free of implanted metal objects or mental shards in eyes
• Fluent in English and capable of consenting

Exclusion Criteria:

• Axis I disorders other than Major Depressive Disorder or PTSD
• Current substance abuse or lifetime substance dependence (other than nicotine)
• High risk for suicide
• Claustrophobia
• Neurological disorders
• Learning disability or developmental delay
• Major medical conditions