Improving Characterization of Calcifications With Contrast-Enhanced Mammography

Improving Characterization of Calcifications With Contrast-Enhanced Mammography

The purpose of this study protocol is to assess whether contrast-enhanced mammography (CEM) will increase the accuracy of characterization of microcalcifications detected on screening mammography prior to biopsy as either benign, high risk, or malignant.

Inclusion Criteria:

• Women with calcifications detected on screening mammogram for which biopsy is recommended following characterization on diagnostic mammography.
• At least 30 years of age.
• Able to understand and willing to sign an IRB-approved written informed consent document
• GFR ≥ 30 mL/min/1.73 m2

Exclusion Criteria:

• Pregnant
• Prior history of allergy or hypersensitivity reaction to iodinated contrast
• History of chronic renal disease (including dialysis, kidney transplant, single kidney, renal cancer, or renal surgery)
• Patients with known thyroid disorders, pheochromocytoma or sickle cell anemia