The aim of our study was to investigate the NK cell activity alternations and related cytokine changes in comparison with soybean oil used formula (control) and the canola and flaxseed oil used n-3 fatty acid enriched formula (n3EN, test) with non-surgical hospitalized patients for rehabilitation.

Patients were randomized to receive one of two types of enteral nutrition formula: soybean oil used enteral nutrition (control), vegetable (canola, flaxseed) derived n-3 fatty acid enriched enteral nutrition (n3EN). Blood samples were collected on the first day and 14 days after consumption of each formula and anthropometric parameters were collected. Hematology and biochemical values were analyzed and NK cell activities and serum cytokine productions were measured.

Inclusion Criteria:

• Patients who were admitted to the Severance Hospital Rehabilitation Department , enteral tube feeding patient, Adult male and female patients aged 19 years and over, Patients who signed the consent form

Exclusion Criteria:

• Patient with nausea
• Patients with hepatic impairment (total bilirubin concentration> 3.5 mg / dl)
• Patients with renal impairment (serum creatinine concentration> 3 mg / dl or requiring peritoneal or hemodialysis) diabetic patients
• Patients who are undergoing chemotherapy or who are within 1 month of the end of chemotherapy
• Patients whose life expectancy is less than 1 month
• Pregnant women and women who are pregnant

The ready-to-use soybean used formula and n3EN formula had identical packaging with no differences in appearance, texture, or smell.