Cell free fetal DNA might predict abnormal placental invasion

This study aims to evaluate whether measurement of cell-free fetal DNA in the maternal plasma can be predictive of abnormal invasion in cases of placenta previa.

Inclusion criteria:

1. Maternal age range from 20-40 years old.
2. Parity: para 1- para 5.
3. Body mass index range from 18-25 kg/m2.
4. Singleton pregnancy carrying male fetuses.
5. Gestational age range from 28-34 weeks.

Exclusion criteria:

1. Multifetal pregnancy.

2. Hypertension, preterm labor and intrauterine growth restriction.

3. Patients taking a tocolytic agent or those with uterine bleeding at or after blood sampling.

   • Since these complications may increase the level of cell-free fetal DNA.

4. Accidental hemorrhage.

Study group (1): 25 women with one or more previous cesarean section and placenta previa anterior only or with ultrasound finding suggestive of placental adhesion or invasion (accreta , increta or percreta).