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Primary purpose of the study is to show wether computed tomography with photon counting detector has a diagnostic image quality as good as, or better than classic computed tomography in investigations concerning stroke work-up.
Images of the skull/brain at the level of the inner ear/temporal bone and the level of nucleus lentiformis will be compared with the same patients routine brain done in TIA (transient ischemic attack)/stroke workup.
Images of the carotid plaque will be compared with the same patients routine CT-angiogram done in TIA/stroke workup.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Not applicable - no intervention. | Other | No intervention is performed, just a CT with a new detector and comparison with the same patients older image. |
| Measure | Description | Time Frame |
|---|---|---|
| Equal or better images vs classic computed tomography. | Are images taken with photon counting detector of brain and vessels worse, equal or better in comparison with ordinary computed tomography. Comparison of images with kernals (or algorithms) for bone and soft tissue at the level of the carotid plaque, inner ear/hindbrain and nucl lentiformis. Comparison of the ability of the spectral function - the ability to separate iodine, soft tissue and calcifications- if applicable. The comparison will be done as a grading (better, equal or worse) regarding the different kernals compared to routine CT exams from the same patient. Significance of difference between proportions with thh use of Fisher's exact test or Pearson's χ2 as appropriate. Evaluation with Cohen´s kappa with 95% CI to assess the level of inter-reader agreement | During 2020 |
| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic information in comparison with MRI | If MRI are performed of the patients brain and/or vessels - a comparison how the diagnostic information is/are relative images from MRI | During 2020 |
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Inclusion Criteria:
Exclusion Criteria:
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All patients in the ordinary stroke workup that do both CT brain and CTA of neck/brain vessel will be asked if we can ask them to participate in this study. Of the ones with carotid stenosis 30% or more we will ask patients to participate in this study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Staffan Holmin, Professor | Contact | +46851777188 | staffan.holmin@ki.se | |
| Magnus Kaijser, Docent | Contact | +46851770000 | magnus.kaijser@ki.se |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Karolinska Institutet, Karolinska University Hospital | Recruiting | Stockholm | 17176 | Sweden |
After the study is completed, contact the Principal Investigator for (anonymous) data
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |