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| ID | Type | Description | Link |
|---|---|---|---|
| R01EY022931-05 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Eye Institute (NEI) | NIH |
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The study will evaluate new methods of retinal stimulation and training with the goal of improving the visual ability of retinal prosthesis participants.
The study will test new ways to make the retinal prosthesis visual perception easier with auditory-visual training and how to make the retinal prosthesis work better at perceiving shapes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Retinal stimulation | Experimental | Alternative stimulus patterns will be tested (vs. baseline). The intervention is the alternative stimulus pattern. The intervention will be tested only in the clinic vs. baseline. The subject will go home with baseline settings. The two alternative stimulus patterns to be tested are asymmetric waveforms and bipolar stimulus. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| New visual processing unit (VPU) with asymmetric waveforms | Device | A VPU will apply asymmetric and symmetric stimulation pulses. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percent change in stimulus thresholds | Compare baseline threshold with threshold of modified stimulus parameters. Threshold is measured in microCoulumbs ( the product of stimulus duration and stimulus amplitude). | Baseline, 8 hours |
| Change in shape perception | As measured by elongation ratio. The elongation ratio is the ratio of major axis length to minor axis length of an ellipse. Subjects will draw shapes on a touch screen and these shapes will be fit to an ellipse. | Baseline, 8 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| James Weiland | Contact | 661-713-4603 | weiland@umich.edu |
| Name | Affiliation | Role |
|---|---|---|
| James Weiland | University of Michigan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Michigan | Recruiting | Ann Arbor | Michigan | 48105 | United States |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Mar 19, 2025 | Apr 8, 2025 | 6 | ||
| Apr 30, 2025 |
| ID | Term |
|---|---|
| D012174 | Retinitis Pigmentosa |
| ID | Term |
|---|---|
| D015785 | Eye Diseases, Hereditary |
| D005128 | Eye Diseases |
| D058499 | Retinal Dystrophies |
| D012162 | Retinal Degeneration |
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| New VPU with bipolar stimulation | Device | A VPU will apply bipolar stimulus pulses. |
|
| May 23, 2025 |
| 7 |
| May 30, 2025 | Jun 17, 2025 | 8 |
| D012164 |
| Retinal Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |